Prostate-specific membrane antigen (PSMA) is a glycoprotein normally located within the intracellular compartment in normal prostate epithelium. However, upon neoplastic transformation, this protein exists as a type II membrane protein. The work using VRPs as a vector system targeting PSMA has been reported in abstract form only (131,132). The full-length PSMA-coding sequence was used for heterologous protein expression in the
VRP system. Mice were immunized with VRPs designed to express this xenoantigen and both antibody and cellular immune responses were identified. Both responses were reflective of a Th1 bias to the elicited immune responses as characterized by cytokine production, IFN-y and IL-4, for CD4 and CD8 T cells by ELISPOT and murine antibody isotype.
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