Carbohydrate Cell Surface Cancer Antigens The Mskcc Experience

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We have screened a variety of malignancies and normal tissues with a series of 40 monoclonal antibodies against 25 antigens that were potential target antigens for immunotherapy (18-21). Results for the 12 defined antigens expressed strongly in 50% or more of biopsy specimens of breast, ovary, prostate cancer, melanoma, sarcoma, and small-cell lung cancer (SCLC) are shown as examples in Table 2. The 13 excluded antigens (including CEA [carcinoembryonic antigen] and HER2/neu) were expressed in 0-2 of the 5-10 specimens.

With the exception of MUC1 and KSA, all of the widely expressed antigens on these cancers were carbohydrates. Our results are consistent with those from other centers with one exception: We did not find increased levels of GD2 or GD3 in SCLC. There is a striking similarity in expression of these 12 antigens among tumors of similar embryo-logic background (i.e., epithelial vs neuroectodermal). Epithelial cancers (breast, ovary,

Table 1

Carbohydrate Cancer Cell-Surface Targets for Vaccine Construction

Tumor Antigensa

Table 1

Carbohydrate Cancer Cell-Surface Targets for Vaccine Construction

Tumor Antigensa

Melanoma

GM2, GD2, GD3

Neuroblastoma

GM2, GD2, GD3, polysialic acid

Sarcoma

GM2, GD2, GD3

Small-cell lung cancer

GM2, fucosyl GM1, polysialic acid, globo H, sialyl Lea

Breast

GM2, globo H, Ley, TF, Tn, sTn

Prostate

GM2, Tn, sTn, TF, Ley

Ovary

GM2, globo H, sTn, TF, Ley

a Antigens present on at least 50% of cancer cells in at least 50% of biopsy specimens.

a Antigens present on at least 50% of cancer cells in at least 50% of biopsy specimens.

Table 2

Proportion of Tumor Specimens With 50% or More of Cells Positive by Immunohistology

Table 2

Proportion of Tumor Specimens With 50% or More of Cells Positive by Immunohistology

Cell Surface Carbohydrate Antigens

Antigen

sTn

Tn

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