TF Tn and sTn Vaccines

Patients with various epithelial cancers have been immunized with unclustered TF-KLH and sTn-KLH vaccines plus various adjuvants (84,85). High-titer IgM and IgG antibodies against TF and sTn antigens resulted. In our hands the majority of the reactivity was against antigenic epitopes present in the vaccine that were not present on naturally expressed mucins (porcine or ovine submaxillary mucins PSM or OSM ) or tumor cells (84,86). Based on previous studies with Tn antigen (87), Kurosaka and...