In Situ Cytokine Gene Therapy

The prostate and bladder are easily accessible for direct intratumoral gene therapy using routine techniques, such as transrectal ultrasound guided needle biopsy of the prostate or cystoscopy and intravesicular instillations of the bladder. Adaptation of these methods to deliver gene therapy vectors has been relatively straightforward, although there have been some difficulties overcoming the efficient gene transfer in the bladder (11). Concerns related to systemic toxicity and cancer cell specificity are generally reduced in local gene therapy applications. In addition to local anti-tumor effects, cytokine genes delivered locally to prostate cancer lesions may induce systemic responses that have therapeutic impact on disseminated cancer cells. This systemic immunotherapy using local cytokine gene therapy is termed in situ cytokine gene therapy or "active vaccine" therapy.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

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