Abate,C., Patel,L., Rauscher,F.J, III, and Curran,T. (1990).

Redox regulation of fos and jun DNA-binding activity in vitro. Science 249, 1157-1161.

Adler.V., Polotskaya,A., Wagner,F., and Kraft,A.S. (1992). Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity. J. Biol. Chem. 267, 17001-17005.

Agarwal,M.L., Agarwal,A., Taylor,W.R., and Stark,G.R. (1995). p53 controls both the G2/M and the G1 cell cycle checkpoints and mediates reversible growth arrest in human fibroblasts. Proc. Natl. Acad. Sci. U. S. A 92, 8493-8497.

Albanese,C., D'Amico,M., Reutens,A.T., Fu,M., Watanabe,G., Lee,R.J., Kitsis,R.N., Henglein,B., Avantaggiati,M., Somasundaram, K., Thimmapaya,B., and Pestell,R.G. (1999). Activation of the cyclin D1 gene by the El A-associated protein p300 through AP-1 inhibits cellular apoptosis. J. Biol. Chem. 274, 34186-34195. Alroy,I., Towers,T.L., and Freedman,L.P. (1995). Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Mol. Cell Biol. 15, 5789-5799. Angel,P., Allegretto,E.A., Okino,S.T„ Hattori,K„ Boyle,W.J., Hunter,T., and Karin,M. (1988a). Oncogene jun encodes a sequence-specific trans-activator similar to AP-1. Nature 332, 166-171.

Angel,P., Hattori,K., Smeal,T., and Karin,M. (1988b). The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 55, 875-885.

Angel,P. and Karin,M. (1991). The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta 1072, 129-157.

Angel,P., Smeal,T., Meek,J., and Karin,M. (1989). Jun and v-jun contain multiple regions that participate in transcriptional activation in an interdependent manner. New Biol. 1, 35-43. Arnulf,B., Villemain,A., Nicot,C., Mordelet,E., Charneau,P., Kersual,J., Zermati,Y., Mauviel,A., Bazarbachi,A., and Hermine,0. (2002). Human T-cell lymphotropic virus oncoprotein Tax represses TGF-beta 1 signaling in human T cells via c-Jun activation: a potential mechanism of HTLV-I leukemogenesis. Blood 100, 4129-4138.

Atfi,A., Djelloul.S., Chastre,E., Davis,R., and Gespach,C. (1997). Evidence for a role of Rho-like GTPases and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) in transforming growth factor beta-mediated signaling. J Biol Chem 272, 1429-32.

Bader,A.G., Hartl.M., and Bister,K. (2000). Conditional cell transformation by doxycycline-controlled expression of the ASV17 v-jun allele. Virology 270, 98-110. Bahassi,e.M., Karyala,S., Tomlinson,C.R., Sartor,M.A., Medvedovic, M., and Hennigan,R.F. (2004). Critical regulation of genes for tumor cell migration by AP-1. Clin. Exp. Metastasis 21, 293-304. Baker,S.J., Kerppola,T.K., Luk,D., Vandenberg,M.T., Marshak, D.R., Curran,T., and Abate,C. (1992). Jun is phosphorylated by several protein kinases at the same sites that are modified in serum-stimulated fibroblasts. Mol. Cell Biol. 12, 4694-4705. Bannister,A.J., Oehler,T., Wilhelm,D., Angel,P., and Kouzarides, T. (1995). Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro. Oncogene 11, 2509-2514. Bassuk,A.G. and Leiden, J.M. (1995). A direct physical association between ETS and AP-1 transcription factors in normal human T cells. Immunity. 3, 223-237. Behre,G., Whitmarsh,A.J., Coghlan,M.P., Hoang,T., Carpenter, C.L., Zhang,D.E., Davis,R.J., and Tenen,D.G. (1999). c-Jun is a JNK-independent coactivator of the PU.l transcription factor. J. Biol. Chem. 274, 4939-4946.

Behrens,A., Jochum,W., Sibilia,M., and Wagner,E.F. (2000). Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 19, 2657-2663. Behrens,A., Sibilia,M., and Wagner,E.F. (1999). Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation. Nat. Genet. 21, 326-329. Bengal,E., Ransone,L., Scharfmann,R., Dwarki,V.J., Tapscott,S.J., Weintraub,H., and Verma,I.M. (1992). Functional antagonism between c-Jun and MyoD proteins: a direct physical association. Cell 68, 507-519.

Berkowitz,E.A., Seroogy,K.B., Schroeder,J.A., Russell,W.E., Evans,E.P., Riedel,R.F., Phillips,H.K., Harrison,C.A., Lee,D.C., and Luetteke,N.C. (1996). Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. Cell Growth Differ 7, 1271-82.

Bianchi,E., Denti,S., Granata,A., Bossi,G., Geginat,J., Villa,A., Rogge,L., and Pardi,R. (2000). Integrin LFA-1 interacts with the transcriptional co-activator JAB1 to modulate AP-1 activity. Nature 404, 617-621.

Bitomsky,N., Bohm,M., and Klempnauer,K.H. (2004). Transformation suppressor protein Pdcd4 interferes with JNK-mediated phosphorylation of c-Jun and recruitment of the coactivator p300 by c-Jun. Oncogene 23, 7484-7493. Blattner,C., Kannouche,P., Litfin,M., Bender,K., Rahmsdorf,H.J., Angulo,J.F., and Herrlich,P. (2000). UV-Induced stabilization of c-fos and other short-lived mRNAs. Mol. Cell Biol. 20, 3616-3625.

Bohmann,D. (1990). Transcription factor phosphorylation: a link between signal transduction and the regulation of gene expression. Cancer Cells 2, 337-344.

Bohmann,D., Bos,T.J., Admon,A., Nishimura,T., Vogt,P.K., and Tjian,R. (1987). Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238, 1386-1392. Bos,T.J., Bohmann,D., Tsuchie,H., Tjian,R., and Vogt,P.K. (1988). v-Jun encodes a nuclear protein with enhancer binding properties of AP-1. Cell 52, 705-712.

Boyle,W.J., Smeal,T., Defize,L.H., Angel,P., Woodgett,J.R., Karin,M., and Hunter,T. (1991). Activation of protein kinase C

decreases phosphorylation of c-Jun at sites that negatively regulate its DNA-binding activity. Cell 64, 573-84. Carter,R., Yumet,G., Pena,A., Soprano,D.R., and Soprano,K.J. (1994). Transcriptional regulation of c-Jun expression during late Gl/S in normal human cells is lost in human tumor cells. Oncogene 9, 2675-2682.

Castellazzi,M., Dangy,J.P., Mechta,F., Hirai,S., Yaniv,M., Samarut,J., Lassailly,A., and Brun,G. (1990). Overexpression of avian or mouse c-jun in primary chick embryo fibroblasts confers a partially transformed phenotype. Oncogene 5, 1541-1547. Chatton,B., Bocco,J.L., Gaire,M., Hauss,C., Reimund,B., Goetz,J., and Kedinger,C. (1993). Transcriptional activation by the adenovirus larger Ela product is mediated by members of the cellular transcription factor ATF family which can directly associate with Ela. Mol. Cell Biol. 13, 561-570. Chen,Y.R., Meyer,C.F., and Tan,T.H. (1996). Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J. Biol. Chem. 271, 631-634.

Chi,H., Sarkisian,M.R., Rakic,P., and Flavell,R.A. (2005). Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development. Proc. Natl. Acad. Sci. U. S. A 102, 3846-3851. Chiu,R., Angel,P., and Karin,M. (1989). Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 59, 979-986.

Chiu,R., Boyle,W.J., Meek,J., Smeal,T., Hunter,T., and Karin,M. (1988). The c-Fos protein interacts with c-Jun/AP-1 to stimulate transcription of AP-1 responsive genes. Cell 54, 541-552. Chopra,S., Fernandez,D.M., Lam,E.W., and Mann,D.J. (2002). Jabl co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kipl. J. Biol. Chem. 277, 32413-32416.

Christerson,L.B„ Vanderbilt,C.A., and Cobb,M.H. (1999). MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions. Cell Motil Cytoskeleton 43, 186-98. Claret,F.X., Hibi,M„ Dhut,S., Toda,T., and Karin,M. (1996). A new group of conserved coactivators that increase the specificity of AP-1 transcription factors. Nature 383, 453-457. Cohen,D.R., Ferreira,P.C., Gentz,R., Franza,B.R., Jr., and Curran,T. (1989). The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 3, 173-184.

Coleman,M.L., Marshall,C.J., and Olson,M.F. (2004). RAS and RHO GTPases in G1 -phase cell-cycle regulation. Nat. Rev. Mol. Cell Biol. 5, 355-366.

Davis,R.J. (1994). MAPKs: new JNK expands the group. Trends Biochem Sci 19, 470-3.

Deak,J.C. and Templeton,D.J. (1997). Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain. Biochem. J. 322 (Pt 1), 185-192. Deng,T. and Karin,M. (1993). JunB differs from c-Jun in its

DNA-binding and dimerization domains, and represses c-Jun by formation of inactive heterodimers. Genes Dev. 7, 479-490. Dennler,S., Prunier,C., Ferrand,N., Gauthier,J.M., and Atfi,A. (2000). c-Jun inhibits transforming growth factor beta-mediated transcription by repressing Smad3 transcriptional activity. J. Biol. Chem. 275, 28858-28865.

Derijard,B„ Hibi,M., Wu,I.H„ Barrett,T„ Su,B., Deng,T„ Karin,M., and Davis,R.J. (1994). JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76, 1025-1037. Devary,Y., Gottlieb,R.A., Lau,L.F., and Karin,M. (1991). Rapid and preferential activation of the c-jun gene during the mammalian UV response. Mol. Cell Biol. 11, 2804-2811. Dhar,A., Hu,J., Reeves,R., Resar,L.M., and Colbum,N.H. (2004). Dominant-negative c-Jun (TAM67) target genes: HMGA1 is required for tumor promoter-induced transformation. Oncogene 23, 4466-4476.

Diener,K., Wang,X.S., Chen,C., Meyer,C.F., Keesler,G., Zukowski, M., Tan,T.H., and Yao,Z. (1997). Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc. Natl. Acad. Sci. U. S. A 94, 9687-9692.

Dumitru,C.D., Ceci,J.D., Tsatsanis,C., Kontoyiannis,D., Stamatakis, K., Lin,J.H., Patriotis,C., Jenkins,N.A., Copeland,N.G., Kollias,G„ and Tsichlis,P.N. (2000). TNF-alpha induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103, 1071-1083.

Eckner,R., Arany,Z., Ewen,M., Sellers,W., and Livingston,D.M. (1994). The adenovirus ElA-associated 300-kD protein exhibits properties of a transcriptional coactivator and belongs to an evolutionarily conserved family. Cold Spring Harb. Symp. Quant. Biol. 59, 85-95.

Edelstein,L.C., Lagos,L., Simmons,M., Tirumalai,H., and Gelinas, C. (2003). NF-kappa B-dependent assembly of an enhanceosome-like complex on the promoter region of apoptosis inhibitor Bfl-l/Al. Mol. Cell Biol. 23, 2749-2761. Eferl,R., Ricci,R., Kenner,L., Zenz,R., David,J.P., Rath,M., and Wagner,E.F. (2003). Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell 112, 181-192. Eferl,R., Sibilia,M., Hilberg,F., Fuchsbichler,A., Kufferath,I., Guertl,B., Zenz,R., Wagner,E.F., and Zatloukal,K. (1999). Functions of c-Jun in liver and heart development. J. Cell Biol. 145, 1049-1061.

Eichhorst,S.T., Muller,M., Li-Weber,M., Schulze-Bergkamen,H., Angel,P., and Krammer,P.H. (2000). A novel AP-1 element in the CD95 ligand promoter is required for induction of apoptosis in hepatocellular carcinoma cells upon treatment with anticancer drugs. Mol. Cell Biol. 20, 7826-7837.

El Tanani,M., Platt-Higgins,A., Rudland,P.S., and Campbell,F.C. (2004). Ets gene PEA3 cooperates with beta-catenin-Lef-1 and c-Jun in regulation of osteopontin transcription. J. Biol. Chem. 279, 20794-20806.

Ellenberger,T.E., Brandl.C.J., Struhl,K„ and Harrison,S.C. (1992). The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted alpha helices: crystal structure of the protein-DNA complex. Cell 71, 1223-1237.

Fan,M., Goodwin,M.E., Birrer,M.J., and Chambers,T.C. (2001). The c-Jun NH(2)-terminal protein kinase/AP-1 pathway is required for efficient apoptosis induced by vinblastine. Cancer Res. 61, 4450-4458.

Faris,M., Latinis,K.M., Kempiak,S.J., Koretzky,G.A., and Nel,A. (1998). Stress-induced Fas ligand expression in T cells is mediated through a MEK kinase 1 -regulated response element in the Fas ligand promoter. Mol Cell Biol 18, 5414-24. Frame,M.C., Wilkie,N.M., Darling,A.J., Chudleigh,A., Pintzas,A., Lang,J.C., and Gillespie,D.A. (1991). Regulation of AP-l/DNA complex formation in vitro. Oncogene 6, 205-209. Franklin,C.C., McCulloch,A.V., and Kraft,A.S. (1995). In vitro association between the Jun protein family and the general transcription factors, TBP and TFIIB. Biochem. J. 305 ( Pt 3), 967-974.

Franklin,C.C., Sanchez,V., Wagner,F., Woodgett,J.R., and Kraft,A.S. (1992). Phorbol ester-induced amino-terminal phosphorylation of human JUN but not JUNB regulates transcriptional activation. Proc. Natl. Acad. Sci. U. S. A 89, 7247-7251.

Gallagher,E.D., Gutowski,S., Sternweis,P.C., and Cobb,M.H. (2004). RhoA binds to the amino terminus of MEKKl and regulates its kinase activity. J. Biol. Chem. 279, 1872-1877. Goldman,P.S., Tran,V.K„ and Goodman,R.H. (1997). The multifunctional role of the co-activator CBP in transcriptional regulation. Recent Prog. Horm. Res. 52, 103-119. Grana,X. and Reddy,E.P. (1995). Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). Oncogene 11, 211-219. Grigoriadis,A.E., Schellander,K., Wang,Z.Q., and Wagner,E.F. (1993). Osteoblasts are target cells for transformation in c-fos transgenic mice. J. Cell Biol. 122, 685-701. Grose,R. (2003). Epithelial migration: open your eyes to c-Jun. Curr. Biol. 13, R678-R680.

Guan,B., Yue,P, Lotan,R., and Sun,S.Y. (2002). Evidence that the human death receptor 4 is regulated by activator protein 1. Oncogene 21, 3121-3129.

Guo,Z., Clydesdale,G., Cheng,J., Kim,K., Gan,L., McConkey,D.J„ Ullrich,S.E., Zhuang,Y., and Su,B. (2002). Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol. Cell Biol. 22,5761-5768.

Hagmeyer,B.M., Angel,P., and van Dam,H. (1995). Modulation of AP-l/ATF transcription factor activity by the adenovirus-El A oncogene products. Biocssays 17, 621-629. Hai,T. and Curran,T. (1991). Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc Natl Acad Sci USA 88, 3720-4. Hai,T.W., Liu,F., Allegretto,E.A., Karin,M., and Green,M.R. (1988). A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1. Genes Dev. 2, 1216-1226.

Halazonetis,T.D., Georgopoulos,K., Greenberg,M.E., and Leder,P. (1988). c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities. Cell 55, 917-924. Haluska,F.G., Huebner,K., Isobe,M., Nishimura,T., Croce,C.M., and Vogt,P.K. (1988). Localization of the human JUN protooncogene to chromosome region lp31-32. Proc. Natl. Acad. Sci. U.S. A 85, 2215-2218.

Ham,J., Babij,C., Whitfield,J., Pfarr,C.M., Lallemand,D., Yaniv, M., and Rubin,L.L. (1995). A c-Jun dominant negative mutant protects sympathetic neurons against programmed cell death. Neuron 14, 927-939.

Hanahan,D. and Weinberg,R.A. (2000). The hallmarks of cancer. Cell 100, 57-70.

Harkin,D.P., Bean,J.M., Miklos,D., Song,Y.H., Truong,V.B., Englert,C., Christians,F.C., Ellisen,L.W., Maheswaran,S., Oliner, J.D., and Haber,D.A. (1999). Induction of GADD45 and JNK/SAPK-dependent apoptosis following inducible expression of BRCA1. Cell 97, 575-586.

Harshman,K.D., Moye-Rowley,W.S., and Parker,C.S. (1988). Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4. Cell 53, 321-330.

Harvey,M., McArthur,M.J., Montgomery,C.A., Jr., Butel,J.S., Bradley,A., and Donehower,L.A. (1993). Spontaneous and carcinogen-induced tumorigenesis in p53-deficient mice. Nat. Genet. 5, 225-229.

Heinrich,R., Livne,E., Ben lzhak,0., and Aronheim,A. (2004). The c-Jun dimerization protein 2 inhibits cell transformation and acts as a tumor suppressor gene. J. Biol. Chem. 279, 5708-5715. Helmberg,A., Auphan,N., Caelles,C., and Karin,M. (1995). Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor. EMBO J. 14, 452-460.

Hibi,M., Lin,A., Smeal,T., Minden,A., and Karin,M. (1993). Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 7,2135-48.

Hilberg,F., Aguzzi,A., Howells,N., and Wagner,E.F. (1993). c-jun is essential for normal mouse development and hepatogenesis. Nature 365, 179-181.

Hilberg,F. and Wagner,E.F. (1992). Embryonic stem (ES) cells lacking functional c-Jun: consequences for growth and differentiation, AP-1 activity and tumorigenicity. Oncogene 7, 2371-2380.

Huang, S., Shu,L., Dilling,M.B., Easton,J., Harwood,F.C., Ichijo,H., and Houghton,P.J. (2003). Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cipl). Mol. Cell 11, 1491-1501.

Huser,M., Luckett,J., Chiloeches,A., Mercer,K., Iwobi,M., Giblett,S., Sun,X.M., Brown,J., Marais,R., and Pritchard,C. (2001). MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951.

Ichijo,H., Nishida,E., Irie,K., ten Dijke,P., Saitoh,M., Moriguchi, T., Takagi,M., Matsumoto,K., Miyazono,K., and Gotoh,Y. (1997). Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90-4.

Ito,T., Yamauchi,M., Nishina,M., Yamamichi,N., Mizutani,T., Ui,M., Murakami,M., and Iba,H. (2001). Identification of SWI.SNF complex subunit BAF60a as a determinant of the transactivation potential of Fos/Jun dimers. J. Biol. Chem. 276, 2852-2857.

Johnson,G.L. and Lapadat,R. (2002). Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298, 1911-1912.

Johnson,R., Spiegelman,B., Hanahan,D., and Wisdom,R. (1996). Cellular transformation and malignancy induced by ras require c-Jun. Mol. Cell Biol. 16, 4504-4511.

Johnson,R.S., van Lingen,B., Papaioannou,V.E., and Spiegelman, B.M. (1993). A null mutation at the c-Jun locus causes embryonic lethality and retarded cell growth in culture. Genes Dev. 7, 1309-1317.

Karin,M. (1991). Signal transduction and gene control. Curr. Opin. Cell Biol. 3, 467-473.

Karin,M„ Liu,Z., and Zandi,E. (1997). AP-1 function and regulation. Curr Opin Cell Biol 9, 240-6.

Kataoka,K., Noda,M., and Nishizawa,M. (1994). Maf nuclear oncoprotein recognizes sequences related to an AP-1 site and forms heterodimers with both Fos and Jun. Mol. Cell Biol. 14,

0 0

Post a comment