Juven-Gershon, T., and Oren, M. (1999). Mdm2: the ups and downs. Mol Med 5, 71-83.

Kadakia, M., Brown, T. L., McGorry, M. M., and Berberich, S. J. (2002). MdmX inhibits Smad transactivation. Oncogene 21, 8776-8785.

Kamijo, T., Weber, J. D., Zambetti, G., Zindy, F., Roussel, M. F., and Sherr, C. J. (1998). Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2. Proc Natl Acad Sci USA 95, 8292-8297.

Kamura, T., Conrad, M. N., Yan, Q., Conaway, R. C., and Conaway, J. W. (1999). The Rbxl subunit of SCF and VHL E3 ubiquitin ligase activates Rubl modification of cullins Cdc53 and Cul2. Genes Dev 13, 2928-2933.

Kannan, K., Kaminski, N., Rechavi, G., Jakob-Hirsch, J., Amariglio, N., and Givol, D. (2001). DNA microarray analysis of genes involved in p53 mediated apoptosis: activation of Apaf-1. Oncogene 20, 3449-3455.

Kastan, M. B., and Zambetti, G. P. (2003). Parc-ing p53 in the cytoplasm. Cell 112, 1-2.

Katan-Khaykovich, Y., and Struhl, K. (2002). Dynamics of global histone acetylation and deacetylation in vivo: rapid restoration of normal histone acetylation status upon removal of activators and repressors. Genes Dev 16, 743-752.

Kawakami, T., Chiba, T., Suzuki, T., Iwai, K., Yamanaka, K., Minato, N., Suzuki, H., Shimbara, N., Hidaka, Y., Osaka, F„ et al. (2001). NEDD8 recruits E2-ubiquitin to SCF E3 ligase. Embo J 20, 4003-4012.

Keller, D. M., Zeng, X., Wang, Y., Zhang, Q. H., Kapoor, M.,

Shu, H., Goodman, R., Lozano, G., Zhao, Y., and Lu, H. (2001).

A DNA damage-induced p53 serine 392 kinase complex contains

CK2, hSptl6, and SSRP1. Mol Cell 7, 283-292.

Kouzarides, T. (2000). Acetylation: a regulatory modification to rival phosphorylation? Embo J 19, 1176-1179.

Kovacs, A., Weber, M. L., Burns, L. J., Jacob, H. S., and

Vercellotti, G. M. (1996). Cytoplasmic sequestration of p53 in cytomegalovirus-infected human endothelial cells. Am J Pathol

149, 1531-1539.

Kubbutat, M. H„ Jones, S. N„ and Vousden, K. H. (1997). Regulation of p53 stability by Mdm2. Nature 387, 299-303. Kubbutat, M. H., and Vousden, K. H. (1997). Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability. Mol Cell Biol 17, 460-468. Kuerbitz, S. J., Plunkett, B. S., Walsh, W. V., and Kastan, M. B. (1992). Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89, 7491-7495. Lammer, D., Mathias, N., Laplaza, J. M., Jiang, W., Liu, Y., Callis, J., Goebl, M., and Estelle, M. (1998). Modification of yeast Cdc53p by the ubiquitin-related protein rublp affects function of the SCFCdc4 complex. Genes Dev 12, 914-926. Langley, E., Pearson, M., Faretta, M., Bauer, U. M., Frye, R. A., Minucci, S., Pelicci, P. G., and Kouzarides, T. (2002). Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Embo J 21, 2383-2396. Leng, R. P., Lin, Y., Ma, W., Wu, H., Lemmers, B., Chung, S., Parant, J. M., Lozano, G., Hakem, R., and Benchimol, S. (2003). Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell 112, 779-791.

Leu, J. I., Dumont, P., Hafey, M., Murphy, M. E., and George, D. L. (2004). Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcll complex. Nat Cell Biol 6, 443-450. Leung, K. M„ Po, L. S„ Tsang, F. C., Siu, W. Y., Lau, A., Ho, H. T., and Poon, R. Y. (2002). The candidate tumor suppressor INGlb can stabilize p53 by disrupting the regulation of p53 by MDM2. Cancer Res 62, 4890-4893.

Levine, A. J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.

Li, M., Brooks, C. L., Wu-Baer, F., Chen, D., Baer, R., and Gu, W.

(2003). Mono- versus polyubiquitination: differential control of p53 fate by Mdm2. Science 302, 1972-1975.

Li, M., Chen, D., Shiloh, A., Luo, J., Nikolaev, A. Y., Qin, j., and

Gu, W. (2002). Deubiquitination of p53 by HAUSP is an important pathway forp53 stabilization. Nature 416, 648-653.

Lill, N. L., Grossman, S. R., Ginsberg, D., DeCaprio, J., and

Livingston, D. M. (1997). Binding and modulation of p53 by p300/CBP coactivators. Nature 387, 823-827.

Lin, Y., Ma, W., and Benchimol, S. (2000). Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Nat Genet 26, 122-127.

Liu, J., Furukawa, M., Matsumoto, T., and Xiong, Y. (2002).

NEDD8 modification of CUL1 dissociates pl20(CANDl), an inhibitor of CUL1-SKP1 binding and SCF ligases. Mol Cell 10, 1511-1518.

Liu, L., Scolnick, D. M., Trievel, R. C., Zhang, H. B., Marmorstein, R., Halazonetis, T. D., and Berger, S. L. (1999). p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19, 1202-1209. Llanos, S., Clark, P. A., Rowe, J., and Peters, G. (2001). Stabilization of p53 by pl4ARF without relocation of MDM2 to the nucleolus. Nat Cell Biol 3, 445-452.

Lohrum, M. A., Ludwig, R. L., Kubbutat, M. H., Hanlon, M., and

Vousden, K. H. (2003). Regulation of HDM2 activity by the ribosomal protein LI 1. Cancer Cell 3, 577-587.

Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., and

Jacks, T. (1993). p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362, 847-849.

Lowe, S. W., and Sherr, C. J. (2003). Tumor suppression by

Ink4a-Arf: progress and puzzles. Curr Opin Genet Dev 13, 77-83.

Ludwig, R. L., Bates, S„ and Vousden, K. H. (1996). Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function. Mol Cell Biol 16, 4952-4960.

Luo, J., Li, M., Tang, Y., Laszkowska, M., Roeder, R. G., and Gu,

W. (2004). Acetylation of p53 augments its site-specific DNA

binding both in vitro and in vivo. Proc Natl Acad Sci USA 101,

0 0

Post a comment