Kick,G., Messer,G„ Plewig,G., Kind,P., and Goetz,A.E. (1996). Strong and prolonged induction of c-jun and c-fos proto-oncogenes by photodynamic therapy. Br. J. Cancer 74, 30-36. Kim,T.K., Kim,T.H„ and Maniatis,T. (1998). Efficient recruitment of TFIIB and CBP-RNA polymerase II holoenzyme by an interferon-beta enhanceosome in vitro. Proc. Natl. Acad. Sci.U. S. A 95, 12191-12196.

King,L.B., Tolosa,E., Lenczowski,J.M., Lu,F., Lind,E.F., Hunziker, R., Petrie,H.T., and Ashwell,J.D. (1999). A dominant-negative mutant of c-Jun inhibits cell cycle progression during the transition of CD4(-)CD8(-) to CD4(+)CD8(+) thymocytes. Int. Immunol. 11, 1203-1216.

Koo,M.S., Kwo,Y.G„ Park,J.H„ Choi,W.J., Billiar,T.R., and Kim,Y.M. (2002). Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. Mol. Cells 13, 194-201.

Kouzarides,T. and Ziff,E. (1988). The role of the leucine zipper in the fos-jun interaction. Nature 336, 646-651.

Kuan,C.Y., Yang,D.D., Samanta Roy,D.R., Davis,R.J., Rakic,P., and Flavell,R.A. (1999). The Jnkl and Jnk2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22, 667-76.

Kyriakis,J.M., Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A., Ahmad,M.F., Avruch,J., and Woodgett,J.R. (1994). The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369, 156-160.

Lamph,W.W., Wamsley,P., Sassone-Corsi,P., and Verma,I.M. (1988). Induction of proto-oncogene JUN/AP-1 by serum and TPA. Nature 334, 629-631.

Landschulz,W.H„ Johnson,P.F., and McKnight,S.L. (1988). The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240, 1759-1764. Lange-Carter,C.A., Pleiman,C.M., Gardner,A.M., Blumer,K.J., and Johnson,G.L. (1993). A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260, 315-9.

Lee,J.S„ See,R.H., Deng,T„ and Shi,Y. (1996). Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300. Mol. Cell Biol. 16, 4312-4326. Lee,S.K„ Kim,H.J„ Na,S.Y., Kim,T.S., Choi,H.S„ Im,S.Y„ and Lee,J.W. (1998). Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. J. Biol. Chem. 273, 16651-16654.

Lee,W., Mitchell,P., and Tjian,R. (1987). Purified transcription factor AP-1 interacts with TPA-inducible enhancer elements. Cell 49, 741-752.

Levine,A.J. (1997). p53, the cellular gatekeeper for growth and division. Cell 88, 323-331.

Li,J.J., Cao,Y., Young,M.R., and Colburn,N.H. (2000). Induced expression of dominant-negative c-jun downregulates NFkappaB and AP-1 target genes and suppresses tumor phenotype in human keratinocytes. Mol. Carcinog. 29, 159-169. Lin,A., Frost,J., Deng,T., Smeal,T., al-Alawi,N., Kikkawa,U., Hunter,T., Brenner,D., and Karin,M. (1992). Casein kinase II is a negative regulator of c-Jun DNA binding and AP-1 activity. Cell 70, 777-89.

Lin,A., Minden,A., Martinetto,H., Claret,F.X., Lange-Carter,C., Mercurio,F., Johnson,G.L., and Karin,M. (1995). Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 268, 286-90.

Logan,S.K., Garabedian,M.J., Campbell,C.E., and Werb,Z. (1996). Synergistic transcriptional activation of the tissue inhibitor of metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors. J. Biol. Chem. 271, 774-782.

Maki,Y., Bos,T.J., Davis,C., Starbuck,M., and Vogt,P.K. (1987). Avian sarcoma virus 17 carries the jun oncogene. Proc. Natl. Acad. Sci. U. S. A 84, 2848-2852.

Mansour,S.J., Matten.W.T., Hermann,A.S., Candia,J.M., Rong,S., Fukasawa,K., Vande Woude,G.F., and Ahn,N.G. (1994).

Transformation of mammalian cells by constitutively active MAP kinase kinase. Science 265, 966-970.

Matsu/awa.A. and Ichijo,H. (2005). Stress-responsive protein kinases in redox-regulated apoptosis signaling. Antioxid. Redox. Signal. 7,472-481.

Mayo,M.W, Steelman,L.S., and McCubrey,J.A. (1994). Phorbol esters support the proliferation of a hematopoietic cell line by upregulating c-jun expression. Oncogene 9, 1999-2008. Minden,A, Lin,A, McMahon,M, Lange-Carter,C, Derijard,B, Davis,R.J, Johnson,G.L, and Karin,M. (1994). Differential activation of ERK and INK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266, 1719-23. Mordret,G. (1993). MAP kinase kinase: a node connecting multiple pathways. Biol. Cell 79, 193-207. Mosieniak,G, Figiel,I, and Kaminska,B. (1997). Cyclosporin A, an immunosuppressive drug, induces programmed cell death in rat C6 glioma cells by a mechanism that involves the AP-1 transcription factor. J. Neurochem. 68, 1142-1149. Muller,S, Berger,M, Lehembre,F, Seeler,J.S, Haupt,Y, and Dejean,A. (2000). c-Jun and p53 activity is modulated by SUMO-1 modification. J. Biol. Chem. 275, 13 321-13329. Munz,C, Psichari,E, Mandilis,D, Lavigne,A.C, Spiliotaki,M, Oehler,T, Davidson,I., Tora,L, Angel,P, and Pintzas,A. (2003). TAF7 (TAFII55) plays a role in the transcription activation by c-Jun. J. Biol. Chem. 278, 21510-21516.

Nakamura,T, Datta,R„ Kharbanda,S„ and Kufe,D. (1991). Regulation of jun and fos gene expression in human monocytes by the macrophage colony-stimulating factor. Cell Growth Differ. 2, 267-272.

Nead,M.A, Baglia,L.A, Antinore,M.J, Ludlow,J.W, and McCance,D.J. (1998). Rb binds c-Jun and activates transcription. EMBO J. 17, 2342-2352.

Neuberg,M, Adamkiewicz,J, Hunter,J.B, and Muller,R. (1989). A Fos protein containing the Jun leucine zipper forms a homodimer which binds to the API binding site. Nature 341, 243-245.

Neyns,B, Teugels,E, Bourgain,C, Birrerand,M, and De Greve,J. (1999). Alteration of jun proto-oncogene status by plasmid transfection affects growth of human ovarian cancer cells. Int. J. Cancer 82, 687-693.

Nikolakaki,E, Coffer,P.J, Hemelsoet,R, WoodgcttJ.R, and Defize,L.H. (1993). Glycogen synthase kinase 3 phosphorylates Jun family members in vitro and negatively regulates their transactivating potential in intact cells. Oncogene 8, 833-840. 0'Shea,E.K, Rutkowski,R, Stafford,W.F, III, and Kim,P.S. (1989). Preferential heterodimer formation by isolated leucine zippers from fos and jun. Science 245, 646-648. Papavassiliou,A.G, Chavrier,C, and Bohmann,D. (1992). Phosphorylation state and DNA-binding activity of c-Jun depend on the intracellular concentration of binding sites. Proc. Natl. Acad. Sci. U. S. A 89, 11562-11565.

Park,J, Kim,I, Oh,Y.J, Lee,K, Han,P.L, and Choi,E.J. (1997).

Activation of c-Jun N-terminal kinase antagonizes an anti-apoptotic action of Bcl-2. J. Biol. Chem. 272, 16725-16728. Peng,S.S, Chen,C.Y, and Shyu,A.B. (1996). Functional characterization of a non-AUUUA AU-rich element from the c-jun proto-oncogene mRNA: evidence for a novel class of AU-rich elements. Mol. Cell Biol. 16, 1490-1499. Pertovaara,L, Sistonen,L, Bos,T.J, Vogt,P.K, Keski-Oja,J, and Alitalo,K. (1989). Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol. Cell Biol. 9, 1255-1262.

Piette,J, Hirai,S, and Yaniv,M. (1988). Constitutive synthesis of activator protein 1 transcription factor after viral transformation of mouse fibroblasts. Proc. Natl. Acad. Sci. U. S. A 85, 3401-3405.

Pomerance,M, Multon,M.C, Parker,F, Venot,C, BlondeauJ.P, Tocque,B, and Schweighoffer,F. (1998). Grb2 interaction with MEK-kinase 1 is involved in regulation of Jun-kinase activities in response to epidermal growth factor. J Biol Chem 273, 24301-4. Potapova.O, Gorospe,M, Dougherty,R.H, Dean,N.M, Gaarde,W.A, and Holbrook,N.J. (2000). Inhibition of c-Jun N-terminal kinase 2 expression suppresses growth and induces apoptosis of human tumor cells in a p53-dependent manner. Mol Cell Biol 20, 1713-22.

Putcha,G.V, Le,S, Frank,S, Besirli,C.G„ Clark,K„ Chu,B, Alix,S, Youle,R.J, LaMarche,A, Maroney,A.C, and Johnson,E.M, Jr. (2003). JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron 38, 899-914. Quantin,B. and Breathnach,R. (1988). Epidermal growth factor stimulates transcription of the c-Jun proto-oncogene in rat fibroblasts. Nature 334, 538-539.

Rauscher,F.J, III, Cohen,D.R, Curran,T„ Bos,T.J, Vogt,P.K, Bohmann,D, Tjian,R, and Franza,B.R, Jr. (1988a). Fos-associated protein p39 is the product of the jun proto-oncogene. Science 240, 1010-1016.

Rauscher,F.J, III, Voulalas,P.J, Franza,B.R, Jr., and Curran,T. (1988b). Fos and Jun bind cooperatively to the AP-1 site: reconstitution in vitro. Genes Dev. 2, 1687-1699. Rebollo,A, Dumoutier,L, RenauldJ.C, Zaballos,A, Ayllon,V, and Martinez,A. (2000). Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and API-like transcription factors. Mol. Cell Biol. 20, 3407-3416. Rincon,M, Whitmarsh,A, Yang,D.D, Weiss,L, Derijard,B, Jayaraj,P, Davis,R.J, and Flavell,R.A. (1998). The JNK pathway regulates the In vivo deletion of immature CD4(+)CD8(+) thymocytes. J. Exp. Med. 188, 1817-1830. Ryder,K, Lau,L.F, and Nathans,D. (1988). A gene activated by growth factors is related to the oncogene v-jun. Proc. Natl. Acad. Sci. U. S. A 85, 1487-1491.

Ryder,K. and Nathans,D. (1988). Induction of protooncogene c-jun by serum growth factors. Proc. Natl. Acad. Sci. U. S. A 85, 8464-8467.

Ryseck.R.P, Hirai.S.I, Yaniv,M, and Bravo,R. (1988).

Transcriptional activation of c-Jun during the G0/G1 transition in mouse fibroblasts. Nature 334, 535-537.

Sawai,H., Okazaki,T., Yamamoto,H., Okano,H., Takeda,Y., Tashima,M., Sawada,H., Okuma,M., Ishikura,H., and Umehara, H. (1995). Requirement of AP-1 for ceramide-induced apoptosis in human leukemia HL-60 cells. J. Biol. Chem. 270, 27326-27331.

Schlesinger,T.K., Fanger,G.R„ Yujiri,T„ and Johnson,G.L. (1998). The TAO of MEKK. Front Biosci 3, 1181-6. Schreiber,M., Kolbus,A., Piu,F., Szabowski,A., Mohle-Steinlein,U., Tian,J., Karin,M., Angel,P., and Wagner,E.F. (1999). Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev. 13, 607-619.

Schrewe,H., Gendron-Maguire,M., Harbison,M.L., and Gridley,T.

(1994). Mice homozygous for a null mutation of activin beta B

are viable and fertile. Mech. Dev. 47, 43-51.

Schumacher,M.A., Goodman,R.H., and Brennan,R.G. (2000).

The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced

DNA binding. J. Biol. Chem. 275, 35242-35247.

Schutte,J., Viallet,J., Nau,M., Segal,S., Fedorko,J., and Minna,J.

(1989). Jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-Jun. Cell 59, 987-997.

Sears,R.C. and Nevins,J.R. (2002). Signaling networks that link cell proliferation and cell fate. J. Biol. Chem. 277, 11617-11620.

Shaulian,E. and Karin,M. (2002). AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4, E131-E136.

Shaulian,E., Schreiber,M., Piu,F., Beeche,M., Wagner,E.F., and Karin,M. (2000). The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest. Cell 103, 897-907.

Sherman,M.L., Stone,R.M., Datta,R., Bernstein,S.H., and Kufe, D.W. (1990). Transcriptional and post-transcriptional regulation of c-Jun expression during monocytic differentiation of human myeloid leukemic cells. J. Biol. Chem. 265, 3320-3323. Short,N.J. (1987). Regulation of transcription. Are some controlling factors more equal than others? Nature 326, 740-741. Siow,Y.L., Kalmar,G.B., Sanghera,J.S„ Tai,G., Oh,S.S„ and Pelech,S.L. (1997). Identification of two essential phosphorylated threonine residues in the catalytic domain of Mekkl. Indirect activation by Pak3 and protein kinase C. J. Biol. Chem. 272, 7586-7594.

Sistonen,L., Holtta,E., Lehvaslaiho,H., Lehtola,L., and Alitalo,K.

(1989). Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase. J. Cell Biol. 109, 1911-1919.

Smeal,T., Binetruy,B., Mercola,D., Grover-Bardwick,A., Heidecker,

G., Rapp,U.R., and Karin,M. (1992). Oncoprotein-mediated signalling cascade stimulates c-Jun activity by phosphorylation of serines 63 and 73. Mol. Cell Biol. 12, 3507-3513.

Smeal,T., Binetruy,B., Mercola,D.A., Birrer,M., and Karin,M.

(1991). Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354, 494-496.

Smith,M.J. and Prochownik,E.V. (1992). Inhibition of c-Jun causes reversible proliferative arrest and withdrawal from the cell cycle. Blood 79, 2107-2115.

Soh,J.W., Mao,Y., Liu,L., Thompson,W.J., Pamukcu,R., and Weinstein,I.B. (2001). Protein kinase G activates the JNK1 pathway via phosphorylation of MEKKl. J Biol Chem 276, 16406-10.

Su,Y.C., Han,J., Xu,S., Cobb,M., and Skolnik,E.Y. (1997). NIK is a new Ste20-related kinase that binds NCK and MEKKl and activates the SAPK/JNK cascade via a conserved regulatory domain. Embo J 16, 1279-90.

Sutherland,C., Renaux,B.S., McKay,D.J., and Walsh,M.P. (1994). Phosphorylation of caldesmon by smooth-muscle casein kinase II. J. Muscle Res. Cell Motil. 15, 440-456.

Tobiume,K., Matsuzawa,A., Takahashi,T., Nishitoh,H., Morita,K., Takeda,K., Minowa,0., Miyazono,K., Noda,T., and Ichijo,H. (2001). ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2, 222-228. Toda,T., Shimanuki,M., and Yanagida,M. (1991). Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev. 5, 60-73.

Toh,W.H., Siddique,M.M., Boominathan.L., Lin,K.W., and Sabapathy,K. (2004). c-Jun regulates the stability and activity of the p53 homologue, p73. J. Biol. Chem. 279, 44713-44722. Tournier,C., Hess,P., Yang,D.D., Xu,J., Turher,T.K., Nimnual,A., Bar-Sagi,D., Jones,S.N., Flavell,R.A„ and Davis,R.J. (2000). Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288, 870-4. Treier,M., Staszewski,L.M., and Bohmann,D. (1994). Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78, 787-798.

Tsuruta,F., Sunayama,J., Mori,Y., aHattori,S., Shimizu,S., Tsujimoto,Y., Yoshioka,K., Masuyama,N., and Gotoh,Y. (2004). JNK promotes Bax translocation to mitochondria through phosphorylation of 14-3-3 proteins. EMBO J. 23, 1889-1899. Ubeda,M., Vallejo,M„ and Habener,J.F. (1999). CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol. Cell Biol. 19, 7589-7599. Uhle,S., Medalia,0., Waldron,R., Dumdey,R., Henklein,P., Bech-Otschir,D., Huang,X., Berse,M., Sperling,J., Schade,R., and Dubiel,W. (2003). Protein kinase CK2 and protein kinase D are associated with the COP9 signalosome. EMBO J. 22, 1302-1312. Verheij,M., Bose,R., Lin,X.H., Yao,B., Jarvis,W.D., Grant,S., Birrer,M.J., Szabo.E., Zon,L.I., Kyriakis,J.M., Haimovitz-Friedman,A., Fuks,Z., and Kolesnick,R.N. (1996). Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature 380, 75-79.

Verma,I.M., Ransone,L.J., Visvader,J., Sassone-Corsi,P., and

Lamph,W.W. (1989). fos-jun Conspiracy: implications for the cell. Princess Takamatsu Symp. 20, 119-126. Verrecchia,F., Vindevoghel,L., Lechleider,R.J., Uitto,J., Roberts, A.B., and Mauviel.A. (2001). Smad3/AP-l interactions control transcriptional responses to TGF-beta in a promoter-specific manner. Oncogene 20, 3332-3340.

Vogt,P.K. and Bos,T.J. (1989). The oncogene jun and nuclear signalling. Trends Biochem. Sci. 14, 172-175. Vries,R.G., Prudenziati.M., Zwartjes,C., Verlaan,M., Kalkhoven, E., and Zantema,A. (2001). A specific lysine in c-Jun is required for transcriptional repression by E1A and is acetylated by p300. EMBO J. 20,6095-6103.

Wang,C.H„ Tsao,Y.P„ Chen,H.J., Chen,H.L„ Wang,H.W., and Chen,S.L. (2000). Transcriptional repression of p21((Wafl/Cipl/ Sdil)) gene by c-Jun through Spl site. Biochem. Biophys. Res. Commun. 270, 303-310.

Weiss,C., Schneider,S., Wagner,E.F., Zhang,X., Seto,E., and Bohmann,D. (2003). JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun. EMBO J. 22, 3686-3695.

Westwick,J.K„ Cox,A.D„ Der,C.J„ Cobb,M.H„ Hibi,M„ Karin, M., and Brenner,D.A. (1994). Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Proc. Natl. Acad. Sci. U. S. A 91, 6030-6034.

Wisdom,R., Johnson,R.S., and Moore,C. (1999). c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms. EMBO J. 18, 188-197.

Wulf,G.M„ Ryo,A., Wulf,G.G„ Lee,S.W., Niu,T., Petkova,V., and Lu,K.P. (2001). Pinl is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin Dl. EMBO J. 20, 3459-3472. Xia,Y. and Karin,M. (2004). The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell Biol. 14, 94-101.

Xia,Y., Makris,C„ Su,B., Li,E„ Yang,J., Nemerow,G.R., and Karin,M. (2000). MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. Proc Natl Acad Sci USA 97, 5243-8.

Xia,Y., Wu,Z„ Su,B., Murray,B., and Karin,M. (1998). JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev 12, 3369-81.

Xia,Z., Dickens,M., Raingeaud,J., Davis,R.J., and Greenberg, M.E. (1995). Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270, 1326-1331. Xu,S., Robbins.D.J., Christerson,L.B., English,J.M., Vanderbilt, C.A., and Cobb,M.H. (1996). Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci USA

Xu,Z., Kukekov,N.V., and Greene,L.A. (2003). POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis. EMBO J. 22, 252-261.

Yan,M., Dai,T., Deak,J.C., Kyriakis,J.M., Zon,L.I., WoodgettJ.R., and Templeton,D.J. (1994). Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372, 798-800.

Yang,D.D., Kuan,C.Y., Whitmarsh,A.J., Rincon,M., Zheng,T.S., Davis,R.J., Rakic,P., and Flavell,R.A. (1997). Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 389, 865-870. Yang,H.S., Knies,J.L„ Stark,C., and Colburn,N.H. (2003). Pdcd4 suppresses tumor phenotype in JB6 cells by inhibiting AP-1 transactivation. Oncogene 22, 3712-3720.

Yang,J., Boerm,M., McCarty,M., Bucana,C., Fidler,I.J., Zhuang, Y., and Su,B. (2000). Mekk3 is essential for early embryonic cardiovascular development. Nat Genet 24, 309-13. Yoshida,K, Yamaguchi,T., Natsume,T., Kufe,D., and Miki,Y. (2005). JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage. Nat. Cell Biol. 7,278-285.

Young,A.P. and Longmore,G.D. (2004). Ras protects Rb family null fibroblasts from cell death: a role for AP-1. J. Biol. Chem. 279, 10931-10938.

Young,M.R., Li,J.J., Rincon,M., Flavell,R.A., Sathyanarayana, B.K., Hunziker,R., and Colburn,N. (1999). Transgenic mice demonstrate AP-1 (activator protein-1) transactivation is required for tumor promotion. Proc. Natl. Acad. Sci. U. S. A 96, 9827-9832.

Yujiri,T., Ware,M., Widmann,C., Oyer,R., Russell,D., Chan,E., Zaitsu,Y., Clarke,P., Tyler,K., Oka,Y., Fanger,G.R., Henson,P., and Johnson,G.L. (2000). MEK kinase 1 gene disruption alters cell migration and c-Jun NH2-terminal kinase regulation but does not cause a measurable defect in NF-kappa B activation. Proc Natl Acad Sci USA 97,1212-1.

Zenz,R., Scheuch,H., Martin,P., Frank,C., Eferl,R., Kenner,L., Sibilia,M., and Wagner,E.F. (2003). c-Jun Regulates Eyelid Closure and Skin Tumor Development through EGFR Signaling. Dev. Cell 4, 879-889.

Zerial,M., Toschi,L., Ryseck,R.P., Schuermann,M., Muller,R., and Bravo,R. (1989). The product of a novel growth factor activated gene, fos B, interacts with JUN proteins enhancing their

DNA binding activity. EMBO J. 8, 805-813.

Zetterberg,A., Larsson,0., and Wiman,K.G. (1995). What is the restriction point? Curr. Opin. Cell Biol. 7, 835-842.

Zhang,L., Deng,M., Parthasarathy,R., Wang,L., Mongan,M.,

Molkentin,J.D., Zheng,Y„ and Xia,Y. (2005). MEKK1 transduces activin signals in keratinocytes to induce actin stress fiber formation and migration. Mol. Cell Biol. 25, 60-65.

Zhang,L„ Wang,W„ Hayashi,Y., Jester,J.V., Birk,D.E„ Gao,M.,

Liu,C.Y., Kao,W.W., Karin,M., and Xia,Y. (2003). A role for

MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure. Embo J 22, 4443-4454. Zhang,X., Wrzeszczynska,M.H., Horvath,C.M., and Darnell,J.E., Jr. (1999a). Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation. Mol. Cell Biol. 19, 7138-7146.

Zhang,Y, Neo,S.Y„ Wang,X„ Han,J., and Lin,S.C. (1999b). Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J. Biol. Chem. 274, 35247-35254.

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