The study of p53 biology and its function as a transcription factor has grown exponentially since it was first discovered in 1982. Still, the precise regulation of this critical transcription factor and the precise sequence of events leading up to its potent activity in the cell cycle remain unclear. Regardless, p53 has a clear implication in tumorigenesis and remains a sought after target for chemotherapeutics. Though little can be done for endogenous p53 that is inactive in tumors, introducing wildtype p53 in this setting may restore critical genetic connections enough to induce an apoptotic response. Understanding p53 function and the pathways that regulate it is also extremely important, as they may yield novel interventions for lowering the likelihood that p53 is inactivated. The future of p53 is open to endless possibilities. Despite continuing complexity, it still remains "the cellular gatekeeper for growth and division" (Levine, 1997).

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