Concluding Remarks

Through more than forty years of research, reversible acetylation of histones catalyzed by a large number of HATs and HDACs has led us to an unprecedented understanding of transcriptional regulation and chromatin remodeling. The realization that reversible acetylation is not restricted to histones and that HATs and HDACs can regulate non-histone protein acetylation further expands the biological functions and significance of protein acetylation. As more evidence suggests a broad involvement of HAT and HDAC proteins in critical biological processes and disease (Fig.6.2), the study of histone acetylation and general protein acetylation promises many important discoveries to come.

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