Molecular Biology Of The Human Sult1a Subfamily

Figure 10.1 shows a dendogram of SULT1A forms isolated from seven species including Homo sapiens (Hsa). It is interesting to note that humans are quite different from other species in having multiple members of the SULT1A subfamily. It is thought that the three human SULT1A members originated as a result of gene duplication or gene duplication plus recombination events (Dooley, 1998a; Rikke and Roy, 1996). Genomic mapping has placed all three SULT1A genes on the short arm of chromosome 16 (position 16p12.1-11.2), which has been confirmed by recent data from the human genome project (NCBI; Aksoy et al., 1994; Dooley and Huang, 1996; Dooley et al., 1993, 1994; Gaedigk et al., 1997; Her et al., 1996; Weinshilboum et al., 1997). Besides the greater than 96% amino acid sequence identity shared between SULT1A1 and SULT1A2, these two enzymes share greater than 93% homology in their gene sequence and are thought to have arisen quite recently in

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