H

Haplotype, intragene, 66 Heated/control ratio, 64

Hematopoietic system, fetal SULT1A expression, 114

Hemostasis, 43

Heparan sulfate, 55

Heterocyclic amines, 181

Heterodimerization, SULTs, 28-29

His108, 33, 198

His123, SULT1A1, 65-66

Homodimerization, SULTs, 28-29

Homovanillic acid, 268

Hormones, inactivation, 43, 179

HUGO Gene Nomenclature Committee, 2

Human Genome Project, 74

Humans

DHEA-sulfate, 80-82 PAPS synthetase, 48 SULT nomenclature, 2-9 Huntington's disease, 158 HxxH motif, PAPS synthetase, 50-51 HXGH motif, 51 Hycanthone, 292

Hydroxamic acids, SULT1A2 activation, 290 V-Hydroxy-2-acetylaminofluorene, 281, 285 mutagenic activity, 281, 283 sulfation, 1, 259-260, 262-266 SULT1A, 202 SULT1A1, 88 SULT1A2, 290 SULT1C, 92-93 SULT1C2, 68 SULT1C4, 13 7-Hydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene, 202

2-Hydroxyamino-5-phenylpyridine, 202 Hydroxybenzylhydrazine, SULT101A1 and, 15 Hydroxychlorobiphenyls, SULT1F sulfation, 14 27-Hydroxycholesterol, 237 Hydroxyindole, sulfation rates, 262 3p-Hydroxyl-5-cholenoic acid, 270

4-Hydroxylonazolac, 291 1-Hydroxymethylpyrene, 284-285, 291, 295

metabolic pathway, 297 SULT1A1 activation, 88, 202

5-Hydroxypropafenone, 165 4-Hydroxypropanalol, stereoselective sulfation,

164-165

17p-Hydroxysteroid dehydrogenase, 136, 149 3 p-Hydroxysteroids, SULT2B1 sulfation, 14 Hydroxysteroid sulfotransferases, 231-232; see also SULT2A1 and 2B1; SULT2 family species differences, 269-271 a-Hydroxytamoxifen, 293 Hypoglycemia, and catecholamine production, 109

Hypoxia, and catecholamine production, 109

Ibuprofen, estrone inhibition, 167 Ile20, and cholesterol specificity, 39 Ile23, and cholesterol specificity, 39 Ile89, and binding specificity, 201 Immunoblots, 111 Immunofluorescence, 112 Immunohistochemical analysis, 112 Immunoreactive protein, decreases in, 67, 68 In-line displacement mechanisms, sulfonate transfer, 198 Inner ring deiodination (IRD), 109-110 T3 sulfate, 123 T4 sulfate, 123 Insects, SULT101 family, 15 Insertions, 10 Intestine, 85, 181 Intracrinolgy concept, 135 Iodothyronine deiodinases, 110, 121-122, 123-124, 129-130 D1, 121, 123-124, 130 D2, 121, 123-124 D3, 121-122, 123-124, 129 Iodothyronines fetal levels, 129, 130 glucuronidation, 122 sulfation, 105, 124 measuring, 111 SULT1A1, 11, 88, 204, 214

SULT1A, 202

SULT enzymes in, 112-113

uterus, 129

Iodothyronine sulfates, fetal levels, 110, 115 Iodothyronine sulfotransferases characterization of, 124-126; see also SULT1 family ontogeny and tissue expression, 127-130 Iopanoic acid, 123

Ishikawa endometrial carcinoma cells (ISH), 141-142

Isoflavanoids, and breast cancer, 145

Isoflavones, sulfation, 1

Isoforms analysis techniques, 111-112 phylogenetic tree, 84 Isoprenaline, 180, 215 Isopreterenol, stereoselective sulfation, 164

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