E

1 4 a * ♦

Fig. 10-1. The utility of fluorescence in situ hybridization (FISH). (A) FISH with spectrum green whole chromosome paint 16 and spectrum orange whole chromosome paint 9 demonstrating an unbalanced 9;16 translocation in a metaphase from an amniotic fluid specimen. (B) FISH with spectrum green locus-specific probes for chromosome 13 band q14 and spectrum orange locus specific probes for chromosome 21 band q11.2-q22.2 in an interphase cell with trisomy 13 from an amniotic fluid specimen. (C) FISH with spectrum green locus-specific probes for chromosome 13 band q14 and spectrum orange locus-specific probes for chromosome 21 q11.2-q22.2 in an interphase cell with trisomy 21 from an amniotic fluid specimen. (D). FISH with spectrum green centromere-specific probes for the X chromosome and spectrum aqua centromere-specific probes for chromosome 18 in an interphase cell with monosomy X from an amniotic fluid specimen. (E) FISH with spectrum green locus-specific probes for chromosome 21 band q11.2-q22.2 in an interphase cell from an amniotic fluid specimen with triploidy.

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