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Activation/deactivation of many metabolic enzymes

Activation of PI 3 kinase to produce inositol 3,4-phosphate and inositol 3.4,5-phosphate which may cause translocation of glucose transporters to cell membrane

Raf protein • kinase (inactive)

■ Rat protein kinase (active)

MAP kinase -(inactive)

MAP kinase (active)

MAP kinase -(inactive)

MAP kinase (active)

Figure 17-2. The insulin receptor and signal transduction events. IRS-1 = insulin receptor substrate; PI 3 kinase = phosphar idyl inositol-3-kinase.

(MAP) kinase, which enters the nucleus, where it activates gene regulatory proteins (e.g., jun) that promote the gene transcription necessary for cell growth and differentiation

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