Ivclassic Liver Lobule Figure 162

A. The classic liver lobule contains a central vein at its center.

B. This lobule also contains six portal triads at its periphery, which consists of: 1. A branch of the hepatic artery

Portal lobule

Classic

Central vein

Portal triads

Liver acinus

Figure 16-2. Diagram of a classic liver lobule and liver acinus. The classic liver lobule contains a central vein at its center with six portal triads at the periphery. The liver acinus defines three zones (zones 1, 2, and 3) based on the location of hepatocytes to incoming blood. Hepatocytes in zone 1 are nearest the incoming blood; hepatocytes in zone 2 are intermediate; and hepatocytes in zone 3 are farthest from the incoming blood. (Reprinted with permission from Henrikson RC, Kaye GI, Mazurkiewicz JE: NMS Histology. Baltimore, Williams and Wilkins, 1997, p 292.)

Portal lobule

Classic

Central vein

Portal triads

Liver acinus

Figure 16-2. Diagram of a classic liver lobule and liver acinus. The classic liver lobule contains a central vein at its center with six portal triads at the periphery. The liver acinus defines three zones (zones 1, 2, and 3) based on the location of hepatocytes to incoming blood. Hepatocytes in zone 1 are nearest the incoming blood; hepatocytes in zone 2 are intermediate; and hepatocytes in zone 3 are farthest from the incoming blood. (Reprinted with permission from Henrikson RC, Kaye GI, Mazurkiewicz JE: NMS Histology. Baltimore, Williams and Wilkins, 1997, p 292.)

a. This artery branch carries oxygenated blood.

b. It contributes 20% of the blood within the liver sinusoids that flows from the periphery to the center of the lobule (i.e., centripetal flow).

2. A branch of the portal vein a. This vein branch carries nutrient-rich blood.

b. It contributes 80% of the centripetal flow.

3. A branch of the bile duct a. This duct branch carries bile collected from bile canaliculi.

b. It carries bile that flows from the center of the lobule to the periphery (i.e., centrifugal flow).

V. LIVER ACINUS (see Figure 16-2) is divided into zone 1, zone 2, and zone 3 based on the location of hepatocytes to incoming blood. Hepatocytes within each zone have specific characteristics, as indicated in the Table 16-1.

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