Selected Photomicrographs

A. Hyperadrenalism (Cushing syndrome), normal adrenal gland, hypoadrenalism (Addison disease) [Figure 23-3]

B. Normal adrenal medulla, pheochromocytoma, neuroblastoma (Figure 23-4)

Figure 23-4. (A) Light micrograph of a normal adrenal medulla showing chromaffin cells and fairly large capillaries. (B) Light micrograph of a pheochromocytoma, which generally appears as a diffuse or nodular hyperplasia. The neoplastic cells are abundant cytoplasm with small centrally located nuclei. The neoplastic cells are separated into clusters by a slender stroma and numerous capillaries. (C) Light micrograph of a neuroblastoma, which is commonly composed of small, primitive-looking cells with dark nuclei and scant cytoplasm. The cells generally are arranged as solid sheets, and some cells arrange around a central fibrillar area, forming Homer-Wright pseudorosetres (asterisk).

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Figure 23-4. (A) Light micrograph of a normal adrenal medulla showing chromaffin cells and fairly large capillaries. (B) Light micrograph of a pheochromocytoma, which generally appears as a diffuse or nodular hyperplasia. The neoplastic cells are abundant cytoplasm with small centrally located nuclei. The neoplastic cells are separated into clusters by a slender stroma and numerous capillaries. (C) Light micrograph of a neuroblastoma, which is commonly composed of small, primitive-looking cells with dark nuclei and scant cytoplasm. The cells generally are arranged as solid sheets, and some cells arrange around a central fibrillar area, forming Homer-Wright pseudorosetres (asterisk).

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