Cerebellar Cortex

I. CYTOARCHITECTURE. The neurons of the cerebellar cortex are arranged in three distinct layers (Table 30-1, Figure 30-1, Figure 30-2). There are five different types of neurons, including:

A. Basket cells are inhibitory neurons that use gamma-aminobutyric acid (GABA) as a neurotransmitter.

B. Stellate cells are inhibitory neurons that use GABA as a neurotransmitter.

C. Purkinje cells are inhibitory neurons that use GABA as a neurotransmitter.

D. Golgi cells are inhibitory neurons that use GABA as a neurotransmitter.

E. Granule cells are excitatory neurons that use glutamate as a neurotransmitter.

Table 30-1

Cytoarchitecture of the Cerebellar Cortex

Layers Name Contents

Table 30-1

Cytoarchitecture of the Cerebellar Cortex

Layers Name Contents

1 Molecular

Basket cells

Stellate cells

Dendrites of Purkinje cells

Dendrites of Golgi cells

Axons of granule cells (parallel fibers)

II Purkinje

Soma of Purkinje cells

III Granular

Soma and axons of Golgi cells

Soma and dendrites of granule cells

Axons of Purkinje cells convey inhibitory output from the cortex to

intracerebellar nuclei

Cerebellar glomerulus

Dendrites of Golgi cells

Axons of granule cells fibers)

Axon of Golgi cell

Mossy fi rosette

Intracerebellar nuclei

Dendrites of Purkinje cells

Mossy fibers (excitatory input) Dendrite of Spinocerebellar tract granule cell Pontocerebellar tract

Vestibulocerebellar tract

Figure 30-1. Cytoarchitecture of the three-layered cerebellar cortex. Axons of Purkinje cells, which are inhibitory, are the only output from this region. A cerebellar glomerulus lies within the granular layer (box). D = basket cell; Gol = Golgi cell; Gr = granule cell; S = stellate cell; + = excitatory; — = inhibitory.

Granular layer

Molecular layer

Intracerebellar nuclei

Purkinje layer

Dendrites of Golgi cells

Axons of granule cells fibers)

Soma of Purkinje cell of Purkinje cells (inhibitory output)

Axon of Golgi cell

Dendrites of Purkinje cells

Mossy fi rosette

Mossy fibers (excitatory input) Dendrite of Spinocerebellar tract granule cell Pontocerebellar tract

Vestibulocerebellar tract

Figure 30-1. Cytoarchitecture of the three-layered cerebellar cortex. Axons of Purkinje cells, which are inhibitory, are the only output from this region. A cerebellar glomerulus lies within the granular layer (box). D = basket cell; Gol = Golgi cell; Gr = granule cell; S = stellate cell; + = excitatory; — = inhibitory.

Figure 30-2. (A) A light micrograph of the cerebellar cortex. The molecular (/), Purkinje (II), and granular (HI) layers are indicated (silver impregnation). (B) A light micrograph of Purkinje cells within layer II. Purkinje cells give rise to an elaborate apical dendritic tree (arrow I) and an axon (arrow 2) (Golgi stain). (Courtesy of Dr. G. Petersen, East Carolina University, School of Medicine, Department of Anatomy and Cell Biology.)

Figure 30-2. (A) A light micrograph of the cerebellar cortex. The molecular (/), Purkinje (II), and granular (HI) layers are indicated (silver impregnation). (B) A light micrograph of Purkinje cells within layer II. Purkinje cells give rise to an elaborate apical dendritic tree (arrow I) and an axon (arrow 2) (Golgi stain). (Courtesy of Dr. G. Petersen, East Carolina University, School of Medicine, Department of Anatomy and Cell Biology.)

Was this article helpful?

0 0

Post a comment