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Several new formulations are being developed, such as topical alprostadil and intranasal apomorphine. New agents are being developed, including selective PDE3/4/ 5 inhibitors: MS-223131 (Bristol-Myers Squibb), T-1032 (Tanabe Seiyaku), TA-1790 (Vivus), sildenafil nitrate (NCX-911) (NicOx); nonselective inhibitors of postsynaptic alpha-adrenoceptors within the corpus cavernosum: phentolamine (Vasomax; Schering Plough), melanocortin receptor agonists such as melatonan II (Palatin) (s.c. and intranasal)—increases erections and sexual drive/appetite (phase 2A)—and the 5HT1 agonist VML670 (Lily/Vernalis).

A recent review of herbal remedies has been scrutenized for potential benefit (103). Examples include L-arginine, yohimbine, and extracts of Tribulus terrestris L. (Protodioscin) that is metabolized to DHEA and which is reported to increase both erections and sexual drive.

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