Male Rat Sexual Behavior

Male rat studies have demonstrated that serotonin (5-HT) and 5-HT receptors are involved in the ejaculatory process. As far as is currently known, 5-HT2C and 5-HT1A receptors determine the speed of ejaculation. For example, studies with D-lysergic acid diethylamide and quipazine, which are nonselective 5-HT2C agonists, suggest that stimulating 5-HT2C receptors delays ejaculation (3). However, 2,5-dimethoxy-4-iodophenyl-2-aminopropane, which equally stimulates 5-HT2A and 5-HT2C receptors, also increases ejaculation latency (4), whereas the selective 5-HT2A receptor agonist 2,5-dimethoxy-4-methylampheta-mine does not have this effect (3). On the other hand, activation of postsynaptic 5-HT1A receptors by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylaminotetralin) in male rats resulted in shorter ejaculation latency (3).

On the basis of these male rat studies, Waldinger (1,5) has hypothesized that premature ejaculation is related to a hypofunction of the 5-HT2C receptor and/or a hyperfunction of the 5-HT1A receptor. In contrast, delayed ejaculation is postulated to be related to a hyperfunction of the 5-HT2C receptor and/or a hypofunction of the 5-HT1A receptor.

5 Secrets to Lasting Longer In The Bedroom

5 Secrets to Lasting Longer In The Bedroom

How to increase your staying power to extend your pleasure-and hers. There are many techniques, exercises and even devices, aids, and drugs to help you last longer in the bedroom. However, in most cases, the main reason most guys don't last long is due to what's going on in their minds, not their bodies.

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