Intimacy Difficulty

See "Theoretical Perspectives" immediately above (11,32,33). Endocrine Abnormalities

Little endocrine research has been done on men with HSDD.

Schiavi et al. compared 17 physically healthy men with HSDD to 17 age-matched non-dysfunctional volunteers (34). All were 25-55 years old. The HSDD men were described as having a generalized and persistent lack of sexual desire. Men with HSDD who did and did not have accompanying erectile problems, were also compared. The authors found that men with HSDD had significantly lower plasma total T levels (but not FT, PRL, LH, or estradiol) measured hourly throughout the night, when compared with controls. As well, they also reported that the men with secondary erectile problems had a different nocturnal penile tumescence (NPT) pattern than those whose erections were not problematic. The authors concluded that there was a relation between the decrease in T and the diminution in sexual drive and speculated that NPT findings may reflect a central biological abnormality. In support of the latter idea, they cited another study in which they found that men with HSDD had a higher prevalence of mood disorders on a lifetime basis (but not at the time of evaluation) and wondered if both mood and sexual desire disorders might represent some neuro-biologic abnormality (35).

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