In addition to hormones, many other changes take place in male physiology which contribute to the aging process. One nonsexual example that is cited for the purpose of providing perspective, is the multiple factors which are associated with diminished bone mass and which include: low estradiol (E2), vitamin D deficiency, low GH, low T, poor nutrition, smoking, certain medications, excess alcohol, inactivity, lack of exercise, poor calcium intake, genetic predisposition, and certain illnesses.

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