Drugs

O'Carroll's review found only one study in which a drug was used thera-peutically by itself for HSDD. The investigation concerned the use of bupropion in a nondepressed population (57). The idea of using bupropion therapeutically resulted from the fact that it is a norepinephrine and dopamine reuptake inhibitor and that dopamine is thought to facilitate many aspects of sexual function including desire. As dopamine is linked to sexual stimulation and pleasure, it was thought that bupropion might be helpful for people with HSDD (58).

The study subjects involved 60 patients of which half were men. All of the patients had low desire and 14/25 men had another sexual dysfunction diagnosis as well. Significantly, more (63%) of the bupropion-treated group reported being much or very much improved (vs. 3% of the placebo group) but changes in the frequency of sexual behavior were "much less dramatic and consisted largely of trends...". Unfortunately, results were not reported separately for men and women (an exception being the statement that "more men (86%) than women (44%) showed... improvement" with the drug).

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