Thrombin is a serine-protease, which is involved in blood coagulation; besides, thrombin triggers various responses in both peripheral tissues and neural cells. The thrombin receptors, which belong to a protease-activated receptor family, have been identified in microglial cells, where they triggered InsP3-induced Ca2+ release and inhibited store-operated Ca2+ entry. Similar receptors are present in astrocytes, where they may be implicated in initiation of reactive gliosis.
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