Neuronalglial synapses

Direct synaptic contacts between neuronal terminals and both NG2-glia and astrocytes have been identified in hippocampus and cerebellum (Figure 6.3). Two types of neuronal-glial synapses, the excitatory glutamatergic synapses and the inhibitory GABAergic, formed by the terminals of pyramidal neurones and interneurones respectively, were recently detected in the hippocampus. These synapses have a typical morphology, revealed by electron microscopy; the latter shows axon terminals, filled with neurotransmitter-containing vesicles, which make synaptic junctions with the processes of glial cells. The neuronal-glial synapses are fully functional, as electric stimulation of nerve axons triggers neurotransmitter release and activation of the AMPA-type glutamate and GABAa receptors residing in the glial membrane. In the cerebellum, NG2-glia receive glutamatergic innervations

Hippocampus Cerebellum

Hippocampus Cerebellum

Electron Microscopy Glia

Figure 6.3 Examples of neuronal-glial synapses. Neuronal-glial synapses were, hitherto, detected in hippocampus, where glutamatergic (send by pyramidal neurones) and GABA-ergic (send by interneurones) neuronal terminals establish synaptic contacts with astrocytes and NG2-glial cells; and in cerebellum, were glutamatergic terminals from climbing fibres form synapses on NG2-glia

Figure 6.3 Examples of neuronal-glial synapses. Neuronal-glial synapses were, hitherto, detected in hippocampus, where glutamatergic (send by pyramidal neurones) and GABA-ergic (send by interneurones) neuronal terminals establish synaptic contacts with astrocytes and NG2-glial cells; and in cerebellum, were glutamatergic terminals from climbing fibres form synapses on NG2-glia from climbing fibres; the terminals of the latter form numerous (up to 70) synaptic junctions on the processes of the glial cell.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

Get My Free Ebook


Post a comment