Ischaemic oedema

Astroglial swelling becomes apparent within 30 minutes of the onset of focal ischaemia. This swelling is quite prominent and water redistribution into the astroglial cells may reduce the total extracellular volume by 50-75 per cent. The initiation of astrocyte swelling upon ischaemia most likely is associated with increased levels of glutamate and K+, which being pumped into astrocytes, trigger the osmotic overload of the latter. This activates water influx through aquaporins, abundantly expressed in astrocyte membranes, and results in the dramatic increase in their volume.

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