Diabetic neuropathies

Diabetic neuropathies are the most frequent complications of diabetes mellitus, which affect ~50 per cent of all patients. Clinically, the sensory neuropathies dominate; motor weakness develops rather rarely. The primary cause of nerve damage is associated with blood glucose levels; aggressive glycaemic control substantially reduces the prevalence of neuropathies. The primary target of the impaired glucose homeostasis is, however, debatable. Traditionally, the leading aetiological factor was associated with abnormalities in neurovascular circulation, which indeed suffers remarkably. According to these theories, the nerve damage was a direct consequence of poor circulation, ischaemia and oxidative injury. Yet, in many cases neuropathies develop without any obvious degradation in neurocirculation. An alternative theory stresses the pathogenetic importance of Schwann cells, which are particularly sensitive to hyperglycaemia; the latter damage glial cells mostly through oxidative stress. Indeed, diabetes is associated with significant morphological abnormalities of Schwann cells and high incidence of their apop-totic death. The obvious consequence of Schwann cells demise is demyelination and reduced nerve conductance velocity, which is the most common symptom of diabetic neuropathy.

Delicious Diabetic Recipes

Delicious Diabetic Recipes

This brilliant guide will teach you how to cook all those delicious recipes for people who have diabetes.

Get My Free Ebook


Post a comment