Astrocyte GABA transporters

The role of astroglial cells in GABA uptake is not very prominent, as the majority of GABA released during neurotransmission is accumulated by both pre- and postsynaptic neurones. Nonetheless, astrocytes do express GABA transporters, and their activity contributes to overall GABA uptake. All three types of GABA transporters, classified as GAT-1 to GAT-3, have been detected in astrocytes; the expression of GAT-3 dominates in cortical and hippocampal astrocytes, whereas cerebellar Bergmann glial cells express GAT-1. GABA transporters use the electrochemical gradient for Na+, and translocation of one GABA molecule requires a cotransportation of two Na+ ions.

How To Reduce Acne Scarring

How To Reduce Acne Scarring

Acne is a name that is famous in its own right, but for all of the wrong reasons. Most teenagers know, and dread, the very word, as it so prevalently wrecks havoc on their faces throughout their adolescent years.

Get My Free Ebook

Post a comment