Astrocyte GABA transporters

The role of astroglial cells in GABA uptake is not very prominent, as the majority of GABA released during neurotransmission is accumulated by both pre- and postsynaptic neurones. Nonetheless, astrocytes do express GABA transporters, and their activity contributes to overall GABA uptake. All three types of GABA transporters, classified as GAT-1 to GAT-3, have been detected in astrocytes; the expression of GAT-3 dominates in cortical and hippocampal astrocytes, whereas cerebellar Bergmann glial cells express GAT-1. GABA transporters use the electrochemical gradient for Na+, and translocation of one GABA molecule requires a cotransportation of two Na+ ions.

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