Mutant Hunts: To Select or to Screen (Perhaps Even by Brute Force)
Carlson, M., B.C. Osmond, & D. Botstein (1981) Genetic evidence for a silent SUC gene in yeast. Genetics 98: 41-54.
Complementation Analysis: How Many Genes are Involved?
Carlson, M., B.C. Osmond, & D. Botstein (1981) Mutants of yeast defective in sucrose utilization. Genetics 98: 25-40.
Neigeborn, L. & M. Carlson (1984) Genes affecting the regulation of SUC2 gene expression by glucose repression in Saccharomyces cerevisiae. Genetics 108: 845-958.
Neigeborn, L. & M. Carlson (1987) Mutations causing constitutive invertase synthesis in yeast: genetic interactions with snf mutations. Genetics 115: 247-253.
Gene Isolation, Characterization, and Multiple Alleles
Neigeborn, L., P. Schwartzberg, R. Reid, & M. Carlson (1986) Null mutations in the SNF3 gene of Saccharomyces cerevisiae cause a different phenotype than do previously isolated missense mutations. Mol Cell. Biol. 6: 3569-3574.
Celenza, J.L., L. Marshall-Carlson, & M. Carlson (1988) The yeast SNF3 gene encodes a glucose transporter homologous to the mammalian protein. Proc. Natl Acad. Sci. USA 85: 2130-2134.
Bisson, L.F., L. Neigeborn, M. Carlson, & D.G. Fraenkel (1987) The SNF3 gene is required for high-affinity glucose transport in Saccharomyces cerevisiae. J. Bacteriol. 169: 16561662.
Carlson, M., B.C. Osmond, L. Neigeborn, & D. Botstein (1984) A suppressor of snf I mutations causes constitutive high-level invertase synthesis in yeast. Genetics 107: 19-32.
Vallier, L.G. & M. Carlson (1994) Synergistic release from glucose repression by migl and ssn mutations in Saccharomyces cerevisiae. Genetics 137: 49-54.
More Suppression and Enhancement
Marshall-Carlson, L., L. Neigeborn, D. Coons, L. Bisson, & M. Carlson (1991) Dominant and recessive suppressors that restore glucose transport in a yeast snß mutant. Genetics 128: 505-512.
Vallier, L.G., D. Coons, L.F. Bisson, & M. Carlson (1994) Altered regulatory responses to glucose are associated with a glucose transport defect in grrl mutants of Saccharomyces cerevisiae. Genetics 136: 1279-1285.
Molecular Genetic Analysis of Suppressor Genes
Ozcan, S., T. Leong, & M. Johnston (1996) Rgtlp of Saccharomyces cerevisiae, a key regulator of glucose-induced genes, is both an activator and a repressor of transcription. Molec. Cell. Biol. 16: 6419-6426.
Ozcan, S., J. Dover, A.G. Rosenwald, S. Wölfl, & M. Johnston (1996) Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression. Proc. Natl Acad. Sei. USA 93: 12428-12432.
Tu, J. & M. Carlson (1995) REGI binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae. EMBO J. 14: 5939-5946.
Analysis of Site-Directed Mutations
Tu, J., W. Song, & M. Carlson (1996) Protein phosphatase type 1 interacts with proteins required for meiosis and other cellular processes in Saccharomyces cerevisiae. Mol. Cell. Biol. 16: 4199-4206.
Baker, S.H., D.L. Frederick, A. Bloecher, & K. Tatchell (1997) Alanine-scanning mutagenesis of protein phosphatase type 1 in the yeast Saccharomyces cerevisiae. Genetics 145: 615-626.
Lutfiyya, L.L., V.R. Iyer, J. DeRisi, M.J. DeVit, P.O. Brown, & M. Johnston (1998) Characterization of three related glucose repressors and genes they regulate in Saccharomyces cerevisiae. Genetics 150: 1377-1391.
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