Reading List

Mutant Hunts: To Select or to Screen (Perhaps Even by Brute Force)

Article 1

Hartwell, L.H. (1967) Macromolecule synthesis in temperature-sensitive mutants of yeast. J. Bacteriol. 93: 1662-1670.

Complementation Analysis: How Many Genes are Involved?

Article 2

Hartwell, L.H., R.K. Mortimer, J. Culotti, & M. Culotti (1973) Genetic control of the cell division cycle in yeast: V. Genetic analysis of cdc mutants. Genetics 74: 267-286.

Epistasis Analysis

Article 3

Hereford, L.M. & L.H. Hartwell (1974). Sequential gene function in the initiation of Saccharomyces cerevisiae DNA synthesis. J. Mol. Biol. 84: 445-461.

Gene Isolation, Characterization, and Multiple Alleles

Article 4

Patterson, M., R.A. Sclafani, W.L. Fangman, & J. Rosamond (1986) Molecular characterization of cell cycle gene CDC7 from Saccharomyces cerevisiae. Mol. Cell. Biol. 6: 15901598.

Article 5

Hollingsworth, R.R., R.M Ostroff, M.B. Klein, L.A. Niswander, & R.A. Sclafani (1992) Molecular genetic studies of the Ccd7 protein kinase and induced mutagenesis in yeast. Genetics 132: 53-62.

Gene Isolation, Characterization, and Multiple Alleles

Article 6

Nasmyth, K.A. & S.I. Reed (1980) Isolation of genes by complementation in yeast: Molecular cloning of a cell-cycle gene. Proc. Natl Acad. Sci. USA 77: 2119-2123.

Article 7

Hadwiger, J.A. & A.T. Lorencz (1985) Protein kinase activity associated with the product of the yeast cell division cycle gene CDC28. Proc. Natl Acad. Sci. USA 82: 4055-4059.

Article 8

Lorencz, A.T. & S.I. Reed (1986) Sequence analysis of temperature-sensitive mutations in the Saccharomyces cerevisiae gene CDC28. Mol. Cell. Biol. 6: 4099-4103.

Suppression Article 9

Reed, S.I., J.A. Hadwiger, H.E. Richardson, & C. Wittenberg (1989) Analysis of the Cdc28 protein kinase complex by dosage suppression. J. Cell Sci. Suppl. 12: 29-37.

Article 10

Kitada, K. L.H. Johnston, T. Sugino, & A. Sugino (1992) Temperature-sensitive cdc7 mutations of Saccharomyces cerevisiae are suppressed by the DBF4 gene, which is required for the Gj/S cell cycle transition. Genetics 131: 21-29.

Article 11

Hardy, C.R.J., O. Dryga, S. Seematter, P.M.B. Pahl, & R.A. Sclafani (1997) mcm5lcdc46-bob-1 by-passes the requirement for the S phase activator Cdc7p. Proc. Natl Acad. Sci. USA 94: 3151-3155.

Enhancement Article 12

Surana, U„ H. Robitsch, C. Price, T. Schuster, I. Fitch, A.B. Futcher, & K.K. Nasmyth (1991) The role of CDC28 and cyclins during mitosis in the budding yeast S. cerevisiae. Cell 65: 145-161.

Two-Hybrid Analysis Article 13

Dowell, S.J., P. Romanowski, & J.F.X. Diffley (1994) Interaction of Dbf4, the Cdc7 protein kinase regulatory subunit, with yeast replication origins in vivo. Science 265: 1243-1246.

Advanced Concepts in Molecular Genetic Analysis Article 14

Ohtoshi, A., T. Miyake, K. Arai, & H. Masai (1997) Analyses of Saccharomyces cerevisiae Cdc7 kinase point mutants: dominant-negative inhibition of DNA replication on overexpression of kinase-negative Cdc7 proteins. Mol. Gen. Genet. 254: 562-570.

Article 15

Hennessy, K.M., A. Lee, E. Chen, & D. Botstein (1991) A group of interacting yeast DNA replication genes. Genes Dev. 5: 958-969.

More Suppression Article 16

Lei, M., Y. Kawasaki, M.R. Young, M. Kihara, A. Sugino, & B.K. Tye (1997) Mcm2 is a target of regulation by Cdc7-Dbf4 during the initiation of DNA synthesis. Genes Dev. 11: 3365-3374.

More Enhancement Article 17

Dohrmann, P.R., G. Oshiro, M. Tecklenburg, & R.A. Sclafani (1999) RAD53 regulates DBF4 independently of checkpont function in Saccharomyces cerevisiae. Genetics 151: 965-977.

Genome-Wide Analysis Article 18

Iyer, V.R., C.E. Horak, C.S. Scafe, D. Botstein, M. Snyder, & P.O. Brown (2001) Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature 409: 533538.

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