The need for a rotavirus vaccine

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Since the golden age of viral gastroenteritis commenced in the early 1970s, many viruses have been implicated as etiological agents of diarrhoeal illnesses. However, rotaviruses reign as the number one cause of severe diarrhoeal disease worldwide, surpassing the enteric adenoviruses, astroviruses, caliciviruses and bacterial agents. Thus, the need for a rotavirus vaccine is clear and compelling, with the goal being the prevention of severe rotavirus diarrhoea during the first two years of life when the consequences of such illnesses are most serious.

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