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higher the "Score" value, the better the match. The "E "value provides a statistical measure of how likely it is to have found this match by random chance. The smaller this value, the more likely it is that the match is meaningful. This tool is commonly used when one first sequences a piece of DNA in order to find the closest match and help identify the gene sequenced. The E value can also find similar genes in closely related or even distantly related organisms. For our example, not surprisingly, the best matches to our Marfan gene piece are to human fibrillin genes. But further down the list, one finds Bos taurus, cow, Sus domesticus, pig, Mus muscu-lus, mouse, and Rattus norvicus, rat genes. If one goes down further, we can even find that the fruit fly, Drosophila melanogaster, has a gene similar to human fibrillin, admittedly with less similarity than the mammals listed above.

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