Glucocorticosteroids have activity against prostate cancer. Their use as sole therapy is limited by long-term side effects including proximal myopathy, osteoporosis, and diabetes mellitus. While one study suggests they are as efficacious as flutamide in patients failing castration,140 in practice glucocorticosteroids are most often used as an adjunct to other therapy, such as aminoglutethimide or mitoxantrone. When used with aminoglutethimide, their primary role is to compensate for suppression of essential gluco-corticoid production by the adrenals.
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