In the United States, feverfew may be marketed as a dietary supplement, but is not approved as a drug. A United States Pharmacopeia advisory panel, although recognizing that feverfew has a long history of use and lack of documented adverse effects, does not recommend its use owing to the paucity of scientific evidence of safety and efficacy. The panel encourages further research, including at least one properly designed clinical trial (4).

In Canada, the Health Protection branch allows sale of tablets and capsules made from feverfew crude dried leaves for decreasing the frequency and severity of migraine headaches. The products should be standardized to contain no less than 0.2% parthenolide. In France, feverfew has traditional use in the treatment of heavy menstrual flow and prevention of migraine headache (4).

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