One study has evaluated the pharmacokinetics of valerian following administration to humans (32). Following administration of a single 600-mg dose of valerian, the pharmacokinetics of valerenic acid were measured. The Tmax occurred between 1 and 2 hours and the Cmax was between 0.9 and 2.3 ng/mL. Concentrations of valerenic acid were measurable for at least 5 hours following the dose. The elimination half-life was approx 1 hour. The authors suggest that based on the expected use of valerian (sedative effects), dosing 30 minutes to 2 hours prior to bedtime would be appropriate based on the previously mentioned pharmacokinetics.

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