Mutagenicity CarcinogenicityTeratogenicity

In 30 patients with migraine who had been taking feverfew leaves, tablets, or capsules for at least 11 months, there was no increase in chromosomal aberrations or sister chromatid exchange in circulating lymphocytes compared to patients with migraine not taking feverfew matched for age and sex. The Ames salmonella mutagenicity test was also performed on urine samples from 10 patients using feverfew and 10 matched nonusers, with no indication of mutagenicity (26).

No problems have been reported in offspring of pregnant women who used feverfew, but feverfew has purportedly been associated with spontaneous abortion in cattle and uterine contractions in term human pregnancies (4).

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