Methamphetamine Manufacture

Either (-)-ephedrine or (+)-pseudoephedrine can be used to make meth-amphetamine by reductive dehalogenation using red phosphorus as a catalyst. If (-)-ephedrine is used as the starting material, the process will generate (+)-methamphetamine. If psuedoephedrine is used, the result will be dextromethamphetamine (136). As this synthetic route has become nearly universal, both state and federal governments have enacted laws limiting the amount of pure ephedrine or pseudoephedrine that can be purchased.

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