Mastodynia

In a 1987, Kubista et al. reported results from a placebo-controlled study comparing the effects of lynestrenol, V. agnus-castus (Mastodynon), and placebo therapy in women with severe mastopathy with cyclic mastalgia. More women in the lynestrenol and V. agnus-castus groups than placebo group reported good relief of PMS symptoms (82, 54, 37%, respectively). Information presented here came from the English abstract of the study, which was published in French (32).

In 1998, Halaska and colleagues examined the tolerability and efficacy of V. agnus-castus extract on mastodynia/mastalgia (breast pain, breast tenderness). The study was a double-blind, placebo-controlled, parallel-group (50 women each) design. Length of treatment (V. agnus-castus [60 drops daily dose] or placebo) was 3 months. Efficacy was determined using a VAS. Results of study showed that the intensity of mastodynia diminished more quickly in the V. agnus-castus group with low incidence of side effects (statistical significance not stated). Information presented here came from the English abstract of the study, which was published in Czech (33).

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