According to the German Commission E Monographs, drug interactions with V. agnus-castus are unknown (10,11). However, with animal experiments showing evidence of a "dopaminergic effect," it is generally recommended that the effect of V. agnus-castus can be diminished in cases when there is concurrent ingestion of dopamine-receptor antagonists (e.g., halo-peridol). Similarly, because V. agnus-castus inhibits the secretion of prolac-tin via a dopamine-agonist action, drug interactions may occur with the D2 family of dopamine-receptor agonists (bromocriptine, pergolide, pramipexole, ropinirole, cabergoline) (5,16).

Some liquid formulations contain large percentages of alcohol (>50% vol); health risks from ethanol may exist, and in certain populations, use of the dried extract formulations instead would be advisable.

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