Follicle Stimulating Hormone Luteinizing Hormone

There are a limited number of human studies regarding how V. agnus-castus directly effects luteinizing hormone (LH) or follicle-stimulating hormone (FSH) (26,27). In a 1994 case report by Cahill et al., a 32-year-old woman undergoing unstimulated in vitro fertilization (IVF) treatment took V. agnus-castus for one cycle without consulting her physician. During this cycle, she had symptoms of mild ovarian hyperstimulation in the luteal phase. Her FSH and LH levels prior to day 13, the predicted day of LH surge in the IVF cycle, were reviewed and found to be much higher than normal. Reviewing five other cycles of this patient and finding normal pituitary gonadotrophin file and normal follicular ovarian responses, the authors suggest that V. agnus-castus was the causative agent (27).

In the 1996 study by Merz et al. that primarily examined prolactin secretion in male subjects, initial hormone levels of FSH and LH were measured on days 1 and 13 (beginning and near-end of placebo phase) and from blood samples taken during the prolactin secretion profiling. The authors state that V. agnus-castus had no effect on FSH or LH levels, but no other details were provided (26,28,29).

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