Endocrine Effects

Kudolo (37) studied the effect of 3-month ingestion of a GBE on pancreatic P-cell function. Having taken a 3-month course of GB, 20 normal, healthy subjects were given an oral glucose tolerance test, and fasting plasma insulin and C-peptide were measured. Fasting plasma insulin area under the curve (AUC) was increased approx 20% whereas C-peptide AUC was increased approx 70%. In a follow-up study in noninsulin-dependent patients with diabetes mellitus who received the same 3-month GB therapy, following an oral glucose tolerance test, a blunted plasma insulin response was noted, leading to a reduction in insulin AUC (38). Conversely, C-peptide levels were increased, leading to a dissimilar insulin/C-peptide ratio. The author suggested this indicated an increased hepatic extraction of insulin relative to C-peptide, potentially resulting in reduced insulin-mediated glucose metabolism and elevated blood glucose.

Administration of GB has also been studied for the treatment of sexual dysfunction. Kang and colleagues evaluated the efficacy of GB administered for 2 months to subjects with antidepressant-induced sexual dysfunction in a placebo-controlled, double-blind design (39). Compared with baseline, both placebo and GB showed improvement in some aspects of sexual function, but there was no difference in effect between placebo and GB treatment. Similarly, Wheatley used a triple-blind, placebo-controlled design to again study the effect of GB on antidepressant-induced sexual dysfunction (40). Again, though some individual subjects experienced improvement, no statistically significant improvement in sexual function was noted.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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