Drug Interactions

In vitro studies suggest that feverfew may inhibit platelet aggregation, leading to recommendations that patients avoid use of feverfew with anticoagulants and medications with antiplatelet activity (4). Platelets from 10 patients who had taken feverfew for at least 3.5 years responded normally to aggregation induced by adenosine diphosphate and thrombin compared to platelets from four control patients who had stopped taking feverfew at least 6 months earlier. In patients who had been taking feverfew for at least 4 years, the threshold for platelet aggregation in response to 11a,9a;-epoxymethanoprostaglandin H2 (U46619) and serotonin was elevated (29). Whether these results translate into the potential for drug interactions and bleeding diatheses remains to be documented.

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