Distribution

Egen-Schwind et al. (78) found that 1,2-vinyl dithiin, a component of oily preparations of garlic, accumulates in fatty tissues, whereas 1,3-vinyl dithiin is more hydrophilic and is rapidly eliminated from serum, kidney, and fat tissue. The latter compound was detected in rat liver over the first 24 hours after administration, whereas 1,2-vinyl dithiin was not. Both 1,3-vinyl dithiin and 1,2-vinyl dithiin were detected in the serum, kidney, and fat. In rats, mice, and dogs, SAC is distributed mainly in the liver, kidney, and plasma (77). In rats, SAC levels are highest in the kidney, and plasma and tissue levels peak 15-30 minutes after oral administration.

Garlic apparently distributes into human amniotic fluid and breast milk. Placebo or garlic oil capsules were given to 10 women 45 minutes prior to routine amniotic fluid sampling. Four of the five amniotic fluid samples from the women who had ingested garlic were judged by a blinded panel to have a stronger and more garlic-like odor than a paired amniotic fluid sample from a woman in the placebo group (79). The ingestion of garlic by nursing mothers was shown to significantly change the perceived odor of milk, as well as significantly increase the amount of time the infant spent attached to the nipple while feeding and the number of sucks during feeding. The total amount of milk ingested by the infants was not significantly affected, however (80). In contrast, these authors later found that the ingestion of garlic for 3 days by nursing women decreased the infants' feeding time compared to infants of mothers who had taken placebo (81).

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