Case Reports of Toxicity Caused By Commercially Available Products

An extensive search of all standard references, as well as reports of studies in humans, shows that there have been no case reports of toxic exposure to V. agnus-castus use. However, one case of nocturnal seizures, possibly attributed to V. agnus-castus, has been reported. The patient was taking concomitantly black cohosh root (Cimicifuga racemosa), V. agnus-castus, and evening primrose as well (34). Thus, attribution of effect to a specific agent was not possible.

In animals, an adverse influence on nursing (lactation) performance has been observed; V. agnus-castus could potentially interfere with proper lactation (15,16).

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