Adverse Effects and Toxicity

The lethal dose of 50% of the population (LD50) of Myrtocyan in rodents is over 2000 mg/kg, and in dogs the only adverse effect from a dose of 3000 mg/kg was dark urine and feces. There is no evidence of mutagenicity, or of teratogenicity or impaired fertility in rats. According to unpublished data of 2295 patients taking Tegens, most of whom took 160 mg twice daily for 1-2 months, 94 subjects complained of adverse effects involving the GI, derma-tological, and nervous system (25).

There are currently no reported adverse effects from the consumption of bilberry or related compounds. When the fruit is consumed in amounts normally contained in foods, bilberry falls under the "Generally Recognized as Safe" category according to the US Food and Drug Administration (26). However, death has been reported with the chronic consumption or high doses of the leaf (1.5 g/[kg ■ day]) (27).

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