In patients who are overweight/obese, clinical focus should be directed first to the risk factors associated with obesity. Most of these risk factors relate to cardiovascular disease, but some may indicate an increased susceptibility to type 2 diabetes. Management of the metabolic risk factors that are characteristic of the metabolic syndrome will be discussed. However, consideration will be given first to management of elevated low-density lipoprotein (LDL) cholesterol, which is the prime risk factor for development of atherosclerotic coronary heart disease.
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