Most recent phylogenetic analyses have placed amphis-baenians as one of three suborders of Squamates (the clade that includes snakes, lizards, and amphisbaenians), but their exact placement within that clade is not well understood. The interrelationships among the four amphisbaenian families are also poorly understood. A recent phylogenetic analysis indicates that trogonophids may be most closely related to the amphisbaenids among amphisbaenians. No significant fossil record exists for this family; a single fossil specimen from Africa is known. Trogonophis is probably the most primitive member of the Trogonophidae, with the highly specialized Agamodon and Diplometopon being the most derived members of the group. No subfamilies are recognized.
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