All pythons are listed as Vulnerable by the IUCN and are on CITES Appendix II. A subspecies of the Indian python, P. m. molurus, is listed as Endangered by IUCN and is on CITES Appendix I. It also is considered Endangered by the U.S. Endangered Species Act. Pythons receive varying degrees of protection in the countries in which they occur. Australia, India, Papua New Guinea, South Africa, and Namibia are notable for the degree of protection they afford to their indigenous pythons. Little is known about the status of any python species in the wild. No baseline population density studies are published. There is anecdotal evidence to suggest that populations of several of the larger species, notably reticulated pythons and Indian pythons, are in decline or have been locally extirpated. At this time there is no evidence that any species is endangered by human activities.
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