Boid snakes tend to be nocturnal, but they are often encountered moving or basking during the day. Faced with a perceived threat, the larger boid snakes typically defend themselves with cloacal discharge, hissing, striking, and biting. When threatened, many sandboas are reluctant to bite and instead roll into a tight ball with their heads in the center; several of the blunt-tailed species then will use their tails to mimic their heads. C. bibroni has been seen to flatten the head and the anterior half of the body, much in the manner of a cobra.

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