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Zolpidem is classified as a hypnotic drug. These drugs help people sleep. In the United States, zolpidem is available as tablets under the brand name of Ambien.


Zolpidem is a drug that is used to treat insomnia. Zolpidem is especially helpful for people who have trouble falling asleep. However, once individuals have fallen asleep, zolpidem also helps them continue to sleep rest-fully. Zolpidem should be used only for short periods, approximately seven to ten days. If sleeping pills are needed for a long period, an evaluation by a physician is recommended to determine if another medical condition is responsible for the insomnia.


Although the way zolpidem helps people sleep is not entirely understood, it is believed to mimic a chemical in the brain called gamma-aminobutyric acid (GABA) that naturally helps to facilitate sleep. Zolpidem is a central nervous system depressant. This means that it slows down the nervous system. Unlike some sleeping pills, zolpidem does not interfere with the quality of sleep or usually leave the user feeling sedated in the morning. As a result, most people using zolpidem usually awake feeling refreshed in the morning.

Recommended dosage

The usual dose of zolpidem in adults is 5-10 mg. For healthy adults, 10 mg is commonly recommended. However, people taking other drugs that cause drowsiness, people who have severe health problems, especially liver disease, and older people (over age 65) should take a lower dose, usually 5 mg. Zolpidem should be taken immediately before bedtime and only if the person can count on getting seven or eight hours of uninterrupted sleep. It usually takes only about 30 minutes for the sleep-inducing actions of zolpidem to be felt. Unlike some sleeping pills, the sleep-facilitating effects appear to last six to eight hours.

If zolpidem is taken with a meal, it will take longer to work. For the fastest sleep onset, it should be taken on an empty stomach. The maximum dose for one day is 10 mg. People who miss a dose of zolpidem should skip the missed dose, and take the next dose at the regularly scheduled time. Under no circumstances should a person take more than 10 mg in one day. Zolpidem should be taken exactly as directed by the prescribing physician.


Because zolpidem is used to help people fall asleep, it should not be used with other drugs (either over-the-counter, herbal, or prescription) that also cause drowsiness (for example, antihistamines or alcohol). Zolpidem should be used only with close physician supervision in people with liver disease and in the elderly, because these individuals are especially sensitive to the sedative properties of zolpidem. Zolpidem should not be used before driving, operating machinery, or performing activities that require mental alertness. People with a history of drug abuse, psychiatric disorders, or depression should be carefully monitored when using zolpidem since zolpidem may worsen symptoms of some psychiatric disorders.

If zolpidem is needed for more than seven to ten days, patients should be re-evaluated by a physician to determine if another disorder is causing their difficulty

Amnesia—A general medical term for loss of memory that is not due to ordinary forgetfulness. Amnesia can be caused by head injuries, brain disease, or epilepsy as well as by dissociation.

Antidepressant—A medication used to treat the symptoms of depression.

Antihistamine—A medication used to alleviate allergy or cold symptoms such as runny nose, itching, hives, watering eyes, or sneezing.

Antipsychotic—A medication used to treat psychotic symptoms of schizophrenia such as hallucinations, delusions and delirium. May be used to treat symptoms in other disorders, as well.

Milligram (mg)—One-thousandth of a gram. A gram is the metric measure that equals approximately 0.035 ounces.

Tuberculosis—An infection caused by the bacteria Mycobacterium tuberculosis that usually affects the lungs. Individuals with tuberculosis may have nighttime sweating, fever, weight loss, cough, and may spit up blood and mucus.

sleeping. When zolpidem or other sleeping pills are used every night for more than a few weeks, they begin to lose their effectiveness and/or people may become dependent upon them to fall asleep. Zolpidem can be habit-forming when taken over a long period. People using zolpidem should not stop taking the drug suddenly, but gradually reduce the dose over a few days before quitting, even if zolpidem has been used only a for short time.

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