Patient Selection Indications for Surgery

The Parkinson's-Reversing Breakthrough

Is There A Cure for Parkinson Disease

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The modern incentive to re-evaluate surgical therapy for Parkinson's disease (PD) has been driven by the realization of the inadequacy of chronic dopaminergic replacement as a main strategy of treatment, namely that dopaminergic replacement treatment is associated with the development of disabling motor fluctuations and dyskinesia (21,22). With disease progression, in some patients, neither parkinsonism nor drug-related side effects can be managed optimally with medications and surgery may be warranted. The primary objective of the surgery is to alleviate dyski-nesia and motor fluctuations (pallidotomy or subthalamotomy) and tremor (thalamotomy).

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