There has been anecdotal evidence of improvement in patients treated with stimulation of the motor cortex for chronic pain (22,23). This has led to the suggestion that stimulation of the motor cortex might be an effective means of treating patients with tremor-dominant PD. A group in Italy has performed motor cortex stimulation for PD in three patients (24-26). They reported that a benefit comparable to STN DBS could be achieved with low-frequency not high-frequency stimulation. Advantages of this procedure might include safer placement, without the risk of deep hemorrhage, and perhaps greater efficacy.
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